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Show M u 0 i, DESERET NEWS, THURSDAY, MAY 13, 1976 Research finds WASHINGTON Rocent OJPI) into the effects of the synthetic estrogen DES, known to cause cancer in women, indicates it can cause far-reachi- reproductive system abnormalities and possible fertility problems in males. The National Institute of Quid Health and Human Development recommended in a report just made available that both sons and daughters of women who took DES (diethylstilbes-trol- ) during the first half of their pregnancies be examined for genital problems after they reach puberty, The Institute based its recommendation on studies conducted at the Univer 1 3 the convertible effects of DES ng sity of Chicagos Lying-iHospital of male and female offspring of women who received DES in an experiment while pregnant 22 years ago. The test then was to see if DES treatment would prevent miscarriages. It did not. DES, a compound derived from coal tar, was used during the 1950s and probably early 1960s to prevent miscarriages. There have been estimates that 500,000 females have been exposed to it. This would suggest as many male offspring also were exposed to DES. Previous studies have shown that DES can cause cancer of the vagina in girls whose mothers took the com pound. The tumors during adolescence. n research A usually urologist, found "severely pathological smien abnormalities in 29 percent of the the 42 young men who had been exposed to DES. appear The Chicago study, directed by Dr. Marluce Bibbo and supported by the institute, looked at 42 males exposed to DES hi their mothers uterus. There were two cases of undersized penes, two cases of undersized testes and four cysts in the seminal duct. There also w as a testicular mass seen but this may have been caused by a previous injury. None of these abnormalities was found in 37 males studied who had not been exposed to DES. In addition. 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