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Show ‘Brief Summary ot Prescribing Information as of Apri 1999, CARDIZEM® CD (diltiazem HC!) Capsules: CONTRAMDICATIONS CARDIZEM Js contraindicated in (1) sesh htheli of a functioning ventricular tr, (2) patients with second- or oe zen te orsanc ol cong wc pace (3)abn peep follid es anc Spl inl Progmancr studies have been conducted in mice, rats, and rabbis. ypotsion GateporyReproduction, Ka f doses engin am v1nes rae(aamobas) than the ‘ecommended therapeutic dose has resulted ‘etal lethality. These doses, in Some sues, have been rapaed fo Cause sila ayormaltes. tthe petaiipesat studies, ere was an nreased Iexdence of siltsdoses f20 nes the human dose ot Pherere fo wacotus ronan women, href,use CARDIZEM npegnant ‘women only i the potential benefit justifies the potential risk to the fetus, in the presence jroe AV block ;), (4) pabents who have demonstatedhypesensty o he acute myocardial infarction and pulmonary congestion documented ay ona WARMINGS "Garde Condeton CARDIZEM prolongs AV node reactor penads witout saneanty rolonging sinus node recovery time, except1ee Seksnus syndrome Th i ay aes th sek Sins syndrome| or sectnd or Tt-dogreAV ick {13 of 2090 ams 8 9 0%) Ce h beta-blockers or diitals result in ‘cardiac conduction. A patient wth Prinzmetal’s angina er S ston)aeundueof60 go cco. 2 Arnougn daar as a neat ioral etc in eolate animal uo roxas,pancaramrude,Tunawth corn velar mnction have not shown a reduction in cardiac index nor ontaciy (api) An aut study of oral itarem in patents |inguin vets function (ejection fraction 24% = 6%) showed improvement in indices of function without decrease net(i tive heat failure has been reported in with proexisti IunctonExpenence wih the use of CARDIZEM (dhlarem hyochore)In cana with beta-blockers in patients with impaired ventricular function is limited. Cauton should be erclad wnan usts combat mon Oscras in blood pressure associated wih CARDIZEM therapy may occasionally result in symptematic hypotension, “4 mersibons of transaminases with without concomit ton in. adaineposrhaase an urn have Den soserves i cuca seco, ‘Such eleva: tions ‘ transient and frequently dittazem treatment rae i in enzymes LOK, SGOT, SGPT and ote pheromaera consistent win ace Napatc mjry been n y Stray08 won| Re Nt reversible upon discontinuation of drug The ratonshin to CARDIZEM is ‘uncertain in some cases,but probable in some, (See PRECAUTIONS.) Sama ine oe Suggests that concentrations in breast milk mayappronaesorvlse of CAR IZEiM Gord eaesy saratve tod ‘nta feeding shou) Mscoccatechins VERSE REACTIONS Stssee er eben a sue ae9 att shouoe acy. that patents wan impaired ventilation and cartiac conduc feal ‘axcluded from studies. The following table presents the most common adverse reactir Controlled angina hypertension trials i paterregROE to ue10360 mp rates with in placebo patents shown for comparso canpizew op Piacobe-Contetlee agen ‘tials Combined a ‘Adverse Reactions * Headache ' Bradearda fe tere ECG Abnormality Asthenia As with Cargizem CD (n=607) Placebo: (n=301) He 3a ; ae 18% fed 1 | ee 23% 18% 17% periods, labora Ot nlltaf CARDIZEM CD coma.CARDIZEM wits. ad ADEM SA Se) were edema (4.6%), sera Oe (2 ‘tasers Nti] (2.4%), bradycardia. (35ere rie 0 pai ou), dosesofae were eosocaed 1 haaut (1.4%) and ), ‘nes eee fae ptowth evo7 oprunsy (ea than 1%) ang or yp cated solachanges fe ve wich wee eerwhen eo tes Gecomined In dogs, doses 20 Nh were iso ase wit Reeea eringeect Or third-degree), bundle branch block, iowever, these changes ‘contiwed dosing veEOD sonal, jon, palpatesyncope, hyd, Dematoagel ev st AOVERSE REACTIONS setona beln od may do Seehattee ear desoite continued use of CARDIZEM. However ski Sonoma deans,ome, presenoa seen, telnet, mmuttforme and/orsa hteyMoos ‘Should a erma- HeronSyiom” Insomnia, nervousness, personaly change somfolece, nats. tremor {ologec reaction persis, the drug should be disc Gastroiniestina!: Anorexia. constipation, diarrhea, igom elevations of SGOT, SGPT, LOH, and alkaline ies) os lnternctions a oe Dus to te pra ox adv eect,caution and cart!trationmarewararad in ptr vomiting, weight increase feng CARDIZEM concoma agemts known to cardiac contractity Other PK aiaon arrefer {See WARMINGS)Pharmacseg “es neahatter. ay be ng ‘oscfee raion roca osturva,va,po tiny“nano (elianings)re eee ialsonics 0 rade ene Teony rug er vere aid neq,patscig jodneys and in bile. rug given over: parameters ‘renal and hepatic tunction pity idnomoretbates ‘The one‘should De used acy Caution in patients with impaired renal or hepatic fur In subacute and chronic CARDIZEM ‘utergos:bauertormanen Oy2Sfctrone FS)Toauncon coe Ge OMe, Teenie eeneet Seed oe[gg tecoeriein (oadministationof route of Ditranstormation may result i CARDIZEM competwith other agents which folow the anc hepatic piped arg heenofsong parteuary oso ow therapeu rao,inpeirnant, may ree ademwhen concomitantly admin Bata-blockers ntrolled CARDIZEM and beta-ocar ivualy wa torte, bt data are not sufficient to the ees of concomtant treatment in patents with et ventcuar aysturcion or tarde conduc 2 faiminisrabon of CARDIZEM (atiazem nyroehonceconcomtanty with propranoio in ve ‘oral volunteers resulted in olivesal suet ad laralabity of propranciol was increased doorniraley vr, propanol appears 0 be doped om ty ditiazem fon.rh. propranolol. an astment inthe propa Clmatiaine. A study in six healthy volunteers has shown a significantincrease in peak ditazem agra wl(SE) an audcr (89%) a 8-ek course of snniion 200 mg per day anda silose ‘mg. Rantine producessah no (can eas! The 4868 aybeds cnet own thio Ot esac cytochrome P-450, beforte stats meabolsm Farts cenaig be carlymontored for 2 ha ect when iain and Gasaranuing eran wih aeidne: Ar Iman tne aiazem dose maybe famanitraon ofCARDICEM thLeIn 24 healthy male subjects inc ‘concent rations note vesioaorfund00 jocase ‘igoun Boose inesipisa cokeaon ms ToactogOe serraeons ey blockers. When Fetopathy” indentnpep a crvce rc eat ney bavents. A umber of wel-documentad cases of generalized ras, character as eukocyo- cevtosotemenss = Prescribing information as of April 1993 Marion Merrell Dow inc. Kansas City, MO 64114 onthe ‘should be titrated cyclosporine has been SteenSig Sees leg 'fle ero" diltiazem and nr ear money, so you should choosethe alternative that does best over the long term—stocks. There will be years when your fund drops sharply. Stocks dothat. But overthe long run, the odds are in yourfavor. If your plan offers an international fund as well as a U.S. fund, split your moneyoverboth. If your employer doesn’toffer a 401(k), you can set up an IRA with almostany mutualfund. If you're self-employed, set up a Keogh Plan or SEP (Simplified Employee Pension). Most important: Start early, The early contributions, compoundedovertime, grow enormously. And Down at the Track... There are three compelling reasons to invest your long-term fundsin stocks: 1. Overthe long run—andit may be very long—stockswill outperform “safer” investments. 2. Stocks offer at least the potential of keeping upwith inflation. Bread could go to $20 loaf, but the companythat bakesit might—might—te able to keep its profits (andits dividend)rising apace. 3. Stockscan actas a tax shelter. Longterm gainsoften get a break. And no tax at all due until yousell. Just rememberthat(the last few years notwithstanding) stocks can go down. Way down. Here’s how somewellknownstocksfaredin the last killer bear market, from their highs of 1972 to their lows of 1974: Avon, down 87%; Coca-Cola, down 70%; IBM, down 56%; Kodak, down 62%; McDonald's, down 72%; Walt Disney, down 86%. ‘That's what real bear markets looklik Butthey pass.A lifetime of periodic investing in no-load stock market mutual funds is the easiest, most prudent course for almost everyone.If you have mutual-fund paralysis, just pick a couple of Vanguard “index funds” (800523-8552). Their hallmark: low expenses.Investing through an index fund, you generally will do better than mostof yourfriends—better than most professionals, in fact—andwith less effort. And because index fundsdolittle trading, they generate few taxable gains. To learn more, try Mutual Funds Magazine(800-442-9000; $9,97 a year). Sermonette 5 Moreis never enough. Thetrickis to enjoythe things that don’t cost much —a sunnyday, a juicy grapefruit,a library book.A friend oncetold me:“It’s as easyto live well when you're pooras when you're rich. But when you're van admesraton of aitaxem with carbamazepine has reported to result in elevate sar Satara (ca) eg in toxicity in some cases, ‘tesa drugs concurrently should be monitored for 2 potential drug interaction poor,it’s much cheaper.” say eaot There was also no mutagenic 1m OF in vivo if call assays oF in vitro intact No evr of mareety as caseda Sy peared m me and O84ES i Adapted from the newly revised “The Only Investment Guide You'll Ever Need,” published this month by Harcourt Brace/Harvest Books. PAGE 16 JANUARY 21, 1996 » PARADE MAGAZINE |
