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Show I ho i I Salt I,ake Tribune, Sunday, October 10, W9 1971 S.L. area women test new drugs for science 4 By Carolyn Monson ine Tribune Staff Writer Would von consider testing a drug not yet approved to be sold on the market? Hundreds of Salt Lake area v.omen are. The Western Gynecological and Obstetrical Clinic Inc., which is staffed by five s. is contracted by pharmaceutical companies to conduct tests on new drugs and clinic patients do the testing. Dr. Howard G. McQuarrie, doc-toi- o principal investigator, explained that human drue in- vestigation is done in phases. Phase one is done for safety. Phase two uses a reistricted population to test the investigational efficiency, drugs chronic toxicity and "usefulness in humans. The Clinic conducts these tests on men and women at the Utah and Nevada State prisons. Prisoners volunteer and are paid for this testing. Phase three is a large scale clinical study and this is where Salt Lake area women a participate. FDA Approval The Clinic, whose reseaich activities require approval of the Federal Drug Administration. has offices in Salt Lake City and Murray. Each office has a research staff. Mrs. Ruth Cundick is to charge of the Salt Lake office, Mrs. Gloria Painter the Murray office and Mrs. Eileen Brooks is overall director. One hundred women are on a test unit, 50 from the Salt Lake office and 50 from the Murray office. O While the dime evaluates many drags, including hormones for estrogen replacement in menopausal women, fertility inducing medications, vaginal infection medications and weight contiol pills, oral and intrauter contraceptives make devices and they are watched closely. up biggest area of testing. Patients who have asked their doctors about oral contraceptives are. at the doctors discretion, referred to either Mrs. Cundick or Mrs. Painter. Women are given full disclosure of the risks involved in doing the testing and adsaid Dr. McQuarvantages, rie. Each signs a release agreement. Th' Clinic began Jesting years ago witn an oral contraceptive that is now off the 10 market. Make Them Safer I expect no new breakthrough in oral contracepsaid Dr. McQuarrie. tives, "Companies are merely altering existing compounds to make them better tolerated and safer. Current evaluations are on oral contraceptives with a dosage and intrauterine devices wound with copper. We do the tests because it keeps us current in the drug field and improves our pharmaceutical knowledge," said Dr. McQuarrie. "Its also good business. Why do the women consent to test drugs? Dr. McQuarrie i feels its be- cause it offers a patient a chance to use new, improved drugs and reduces the patients health care costs since drugs are provided free as are physical and laboratory- examinations. Strict Protocol The women also have confident ... their own physicians. They know that if a problem should develop they can get nght in to see the doctor. Weve been fortunate with the drugs. said Dr. McQuarrie. Weve had no serious side effects. They've been good drugs. Actually, these test dugs are safer and better than the first approved oral contraceptives on the market, said Mrs. and Mrs. Painter Brooks. The two directors talk a great deal to husbands. This was a surprise to Mrs. Cunwho started on the research program six years ago. Men are not at all dick, the idea of planned about calling up and asking questions. They want to know all about the program and what to expect. parent- reports of the danger of oral contraceptives come out and are announced Whenever and on television, both olfii.es ate flooded with calls. Each woman who is going to drop the pill is to the doctor for advice and while some do, most do not as a result of nonemotion-al- . rational counseling. The tests last varying degrees of time, depending on what facts are needed. in newspapets Require 2 used ir. the studies with the majority in the 18 to 33 age you can't take an isolated report of sile effects from one person as valid," he said. Evety woman reacts differently to a drug," said Mrs. Cundick. "That's why there's such a wide variety of pills available. One is better suited than to a certain woman another. Women from 18 to 40 ate Years r The estrogen dosage pills will require about two years. At the end of that time ate sent to the drug company which puts the information into a computer for a on results. print-ou- t asThe more interesting pects of the tests are published by Dr. McQuarrie. Ive learned a lot about drugs and drug abuse," said Dr. McQuarrie. "Also, that low bracket. Some contraceptive studies oth- require proven fertility, ers do not. Most of the women who have been on one of the programs like them and ask to participate again," said Mrs. Cundick. STYLE CLOTHING SIZES 40-6- 0 ,. 16V2-321- DAHLES Queen acv FASHIONS V 48 West 2nd So. m J 361-418- 0 Theres Problems a theres Occasionally. problem, when the wife has not explained the program and the husband feels his wife is a guinea pig and taking gieat risks. Mrs. Cundick and Mrs. Painter explain the program to the worried husband and he is then all for it. There are also some women w ho use the tests as an excuse to manipulate marital discord and the result is an irate phone call from the husband. Some husbands become so interested they come in with for monthly their wives checks and a supply of new POSH ROBES AT patient, get into the office for said Dr. McQuarcheckups, rie. Mrs. Cundick. Mrs. Painter and Mrs. Brooks agreed that women like the attention. They atoays have cnninonp to call if they have a question know the consequences if they should forget. Test directois have learned s some things about oral any woman would do well to know. Diarrhea and or vomiting voids tne pill's effectiveness against pregnancy- s SPECIAL PRICES BY 4 tf Two alluring robes to grace your own wardrobe or save for gift occasions to come. Both are completely washable, elegantly styled. pills. Women no longer have a problem remembering to take the pill, said Mrs. Cundick. Its automatic now. They of Painter's. The Murray directors also feel that Mrs. Cundicks women are most receptive to hood. the strict protocol required on tests, someone is insisting that you, the "Because ami if a pill should be foi gotten, never take two the next This night to compensate. merely raises the drug level in your system which drops drastically when only one pill is taken again. This also could result in pregnancy. Mrs. Cundtok's patients aie mostly working women. The Murray office deals mostly with housewives. The housewife seems to be more prone to worry about symptoms than the working girl. 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