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Show Page A6 THE DAILY HERALD, Provo, Utah, Thursday, November 21, 19 Drug company defends use of homeless for experiments - By RICK CALLAHAN Associated Press Writer INDIANAPOLIS John Carter spent eight weeks cooped jl. up in a research lab as a human pig for an Eli Lilly & Co. g experiment. vVhen the test was over, he got a $4,20() check for his trouble, 4hich included having his blood drawn repeatedly but no side effects from a drug he knew only f Two days later, decked out in new clothes. Carter bought some liquor and invited a woman to his newly rented apartment. When he awoke from a drunken stupor, the woman and his money were he said. gone, ! "1 had a lot of plans for that money." Carter, 35, said Tuesday, recalling his dashed .itopes"? of attending bartending thool,wit i as easy money for just beirlg a guinea pig, but it's gone." , Carter is among many hoftl$es--rfien who have particiDatefiite pharmaceutical company Vre2$f. Jinical trials over the ytfawlS' trials determine whether drugs are sufe and how to adjust doses before they are given to actual patients in rthuse II trials. While some in the industry have questioned tMl$-rac- y of trials on homeless people 4-- a group more prone to and drug abuse - ItsSt anapolis-base- d Lilly maifflaiffistwSt u;sing society's outcasts dr$r?f threaten the trials' integrity. The Wall Street Journal reported s last week that some homeless said they participated in Lilly's trials shortly after drinking binges. Prospective volunteers, however, undergo a series of tests that weed out alcoholics and drug abusers, and those who suffer from chronic conditions such as heart, lung or liver disease, said Lilly spokesman Ed West. The goal is to select or'' healthy volunteers. "Any individual that has a severe medical condition or liver disease related to drinking is going to be detected ... and eliminated," West said. "They'll have no impact on the data." Since 1988, 94 percent of Lilly's volunteers listed permanent addresses on applications, although the company doesn't routinely verify the information, West ' rigm ! alco-hjolis- m alco-hqlic- f ' ' fit v ft in the AP Ptioto today. James Ash sits inside the Lighthouse Mission in Indianapolis recently. Ash is among scores of homeless people who have taken part in drug i,'. 3iKpwimnts for Eli Lilly & Co. satd. Volunteers also must sign an lffformed-conseform before they can participate. Some critics say that because homeless or impoverished volun-1teeare desperate for money, they 'sometimes don't mention side f fTects from the drugs for fear of being ejected from trials. "There's always the concern (hat they might not necessarily be "telling the truth. ... They basically "ell you what you want to hear," said Philip Brown, a physician at Pharmaceutical Research Associates, based in Charlottesville, Va. He also said Lilly's screening process, which includes urine tests and physical exams, might not be sophisticated enough to detect alcoholics suffering from the early stages of liver disease. Determining which volunteers have the disease is important because most drugs are metabolized by the liver. But West said that even if volunteers with "mild liver dysfunction" made it through the screening process, they would not taint data. Clinic staffers could lower doses, an adjustment necessary because impaired livers metabolize drugs slower. homeJames Ash. a less man who says he participated in a monthlong Lilly trial during the summer, earned aboui S2.000. much of which he gambled away on horses. Ash said many of his friends spend their Lilly earnings on drugs and prostitutes. "It's easier for. a homeless person to get drug's than anyone else. They know where just about everything is." Officials with some local church-ru- n missions said privately that Lilly's trials undermine their efforts to help the homeless. One official, who spoke on condition of anonymity, feared that the Lilly Endowment, which provides some funding for his shelter, would retaliate if he complained publicly. The Lilly Endowment, though financed through Lilly stock, is independent of the company. Many local homeless shelters post the names and numbers of drug companies seeking volunteers. Among them is Horizon House, whose executive director said she has no qualms about providing the information. "The point is that they're legally earning the money. Some people use it to buy cars, get an apartment or set themselves straight," Lena Hackett said. "I don't think it's my place or anyone else's place to tell a homeless person. 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