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Show DES'RET New Miracle Drugs Awaiting Release By RUTH WINTER Waiting to be released by the U.S. Food and Drug Administration are a number of super drugs which promise to alleviate mental and physical suffering for millions. They include a powerful potion for victims of Parkinson's disease, an inexpensive drug for the prevention of depression and mania, lithium carbonate; and a seemingly miracle drug, DMSO If these drugs are so useful, why haven't they been released? Is the FDA holding them up to protect us from another Thalidomide tragedy since all the drugs mentioned have serior is the agency stranous side effects gled ir its own red tape? Stricter FDA requirements concerning new drugs have led to applications containing 13,000 pages of research reports. In addition, the FDA h s lost the services of the 70 Public Health Service physicians it borrowed to help relieve its backlog of work. The agency also sustained a $4 million budget cut this year. Law requires that the FDA rule on a new drug application within 180 days. Dr. Jamer Goddard, the former commissioner. claims that when he left office July 1, 1908, the FDA was current with its new applications. Dr. Herbert Ly, Jr., the in present commissi;, er, admitted March that the agency was running behind on 30 of the current 149 new drug applications. In recent years, the fastest a drug wis even put on the market was seven months. This was Talwin, a supposedly powerful pain killer. Now, new information indicates that Talwin may be addicting and is not as powerful a pain killer as previously supposed. . FpAs slowness to release drugs may be of ultimate benefit to the public, as in the case of Thalidomide, the safe tranquilizer that crippled unborn babies. On the other hand, the slowness may be a disaster to the millions who might benefit from the new compounds. Here is a ' rundown on them : - Happy End To Car $ Bv HARRY JONES My career as a chauffeur has come lo a grinding halt. It was a career w hich spanned several years beginning whj the oldest of our elan started kindergarten. And because, Ihe school was on the route to the office , where I slaved at the time, I was elected ' the director of the neighborhood motor pool. It meant that I dropped off the kids . , at school on my way to woik. Those were hectic days. There was .it one child named Taffy. She just couldn't be pulled from her mother in the morn' ing. After pleading, coaxing, and promis- loose' would her mother ing, pry Taffy and put her in the back seat of the wagon. That kid kicked, cried, jimj , screamed all the way to school, I hate' you, she would yell at me. This went oil through kindergarten, the .first and Sec- ond grades. The family moved to St. Louis . the second grade. As far as I know, tiiat kid is yelling still. But those tikes really knew what wqs going on in the neighborhood and would confide in me. They told me who wad w hat fighting with whom every neighbor thought of the others. These , kids had a key to every c'nset with ,J skeleton. One day, a little girl named Tina told me that her mom was going to have 'at baby. I met her father in town and congratulated him. He was quite surpri$ec ,itJ T and called home to verify the news. was a little upset that I knew before' he ' did. It got so that I DMSO Dimethyl sultoxide was bet aided in the public and medical press as a multipurpose miracle drug in 1963 when its clinical trials began. By November, 1963, the FDA halted all clinical testing. In June, 1967, the drug became available on prescription in Germany and Austria and in September, 1968, the FDA loosened its restrictions on clinical testing. to its medical DMSO, according father, Dr,. Stanley W. Jacobs of the University of Oregon Medical School, has Doctors there studied 34 patients who were put on the medication. They "reported results were modest in five patients; moderate in six; marked in 13, and dramatic in 10. With few exceptions, the improvement was sustained for up to two vears on daily doses of that from four to eight grams per day. The drug has also been successfully used in dystonia, which results in a gro tesque deformity from abnormal tightening of the muscles, and in manganese potent when poisoning. Side effects included nausea and and, most serious, dyskivomiting nesia. or difficulty in performing volun- . tary movements. One pharmaceutical firm has filed a new drug application P'r a refined form of which may make smaller doses of the drug possible and do away with some of the side eflects! In spite of great pressure, the drug is not expected to be released soon. However, before it is released it may be outdated. In another case of happy accident, woman was given a drug, a amantadine hydrochloride, to protect her from the flu. Her Parkinson symptoms improved. The benefits of the drug were proved for flu prevention firmed in 173 more Parkinson cases. apcon- Lithium Carbonate Lithium Nathan S. has been termed by Dr. Kline, the psychiatrist at State Hospital who did the Rockland basic clinical testing of modern tranquil-- , izers, as the most exciting new thing in psychiatry. Lithium has been found to significantly reduce both the manic and the de- - properties tested in arthritics. It is also a killer of tungus, bacteria and viruses. It prevents clotting and, in low doses, relieves pain. DMSO produces muscle relaxation about one hour after application to 1 afr ... human skin. It dissolves deposits of collagen in scar tissue and softens the leathery skin of scleroderma victims. . a' The major side effect has been eye changes noted in experimental animals. Such changes have not been found in people. Commissioner Ley says that "tests with human volunteers have established that short-teruse of DMSO is reasonably safe. One drug company is still clinically testing the drug, but there is little hope that it will be released soon. IN. 1 1 (14-da- (c) ' Pool Days tppli-cation- d Parkinsonism is a chronic disorder of the central nervous sytem characterized by slowness of purposeful movement, OUR f.lAIl J0EIE5 depressed. The FDA has been beseiged by plivsi-cian- s who want to test the drug on their patients. But few American drug firms are interested in pursuing the drug because it is inexpensive and readily available from chemical houses. Therefore, the profits would be slight. Under pressure, three pharmaceutical houses recently filed applications to mans ufacture it for general use. These ate approaching the approval stage. says Dr. John Jennings, acting director of FDAs buteau of medicine. Side effects trom lithium, which must be given at close to toxic doses, include of goiters, a growth in the devel-'iiie- nt the thyroid gland, and kidney and heart damage to susceptible people. weakness, muscular rigidity and tiemor. to treat The successful use of this disease evolved out of a researcli program at Brookhaven National Laboratory, Upton, N.Y. 5 23, 196? September r over-excite- d After treatment with new drug called he is able to walk well; even to leawi hospital grounds. J Tuesday, pressne stages of mental illness in which or deeply patients are either This patient, suffering from Parkinson's disease, spent most of time standing immobile in corridors. NEWS 1 World look Sorvlce 4 MERRY-GO-ROUN- D Strategy Of Silence Greets Inflation Spiral WASHINGTON The silence seems unreal but there is no sign yet that the White House has been sufficiently rocked by the gathering wave of price increases to bring the have moved on to advocate controls, a drift which Chairman William Martin is doing his best to power of the into play against inflation. Richard ons economic visors their y Nixad- po 1 i c y of presidential si- - ment that the screws already applied to the economy will soon turn it in a more direction. But It- is also clear .'stable halt. i ' ' there will be a painful the ' The White House attitude nas deep actual turn and the end of the surge of roots. As far back as 1966, Arthur Burns prices and wages. Price increases in raw argued that wage-pric- e guideposts were materials must emerge in the finished a threat to free markets, that presidenproducts. Labor will react as long as tial intercession was capricious and disprices rise. Inflation has a scorpions criminatory and potentially damaging tail. to the prestige of the men who head the The need to deal more ruggedly with government. He warned that voluntary wage-pric- e restraints could lead easily to this tail is particularly felt by the labor direct controls. leaders, far less sanguine than the White House economists that a rising rate of Two opportunities have, however, will cool off wage unemployment drawn the administration out of its shell. demands. The White House is betting on A move against lumber the disposition of businessmen to play a prices in produced a 40 per cent price reduction in a matter of tighter hand as their profit margins narrow. The labor leaders sense they are weeks. The new cutback in public works being pushed toward an ugly confrontaand the formation of a tion, by the mpod of the rank and file. committee on construction problems are basically aimed at the building This mood is already inducing a clitrade locals, whose wage increases have mate in which reasonable settlements do averaged 15 per cent this year. not settle wage disputes. The leaders Confidence grows within the govern describe their members as excited and governors wage-pric- e persuasive presi-denc- CHARLES BARTLETT I i Mr. Bartlett lence after the big steel price rise in late July. They concluded then that Mr. Nixon should ride out the inflationary storm without exposing himself to the bitterness and uncertain consequences of intervention in the free market process. Several governors of the Federal Reserve Board have entreated the administration to add its vocal weight to the counter inflationary pressures of monetary and fiscal policy. But the strategy of silence is so deeply embedded in White House thinking that the Fed members hold little hope for change. One or two YOUR HEALTH - mid-wint- scared by the pace of inflation, fearful they are slipping backward in the economic scale. The workers show more taste for confrontation than for settlement and the leaders are uncomfortably aware that they will need to fight it out to prove they are not lying down. Thus the scorpions tail augurs an unhappy period of bitter disputes with damaging social and economic consequences. This is a prospect against which a president might reasonably be expected to exert his full influence. None of those officials in the Demo- cratic administrations who struggled for wage-pric- e stability with all the available levers believe they achieved the ultimate in an incomes policy In fact no industrial society has found what it considers a satisfactory answer. But the Nixon Administration, in reverting to total reliance on free market forces, seems to have given up the search. The moves against lumber and the building trades suggest that a highly cautious spirit of activism lurks beuind the White House silence. The President needs now to be less cautious and more emphatic in declaring his goal of stability. Soloists Named For Salute To Youth las By HAROLD LUNDSTROM MUSICAL WHIRL advanced string categories have been recommended and auditioned. Mr. Abravanel also has the always Please mark down October 15! This is difficult task of a music director that the day when six musicians and four of putting together a program of merit. lect singers above 21 if they meet his arsingers will reach it big. They will pere tistic demands. This means that sometimes the M.D. C. GEORGE THOSTESON, form .with By the and winner has not been a guest soloist beinstrumentalists Performers, Dear Dr. Thosteson: My son, 7, Utah Symphony cause his major competition piece has singers, should be unmarried. O r c h estra and No one should appear in two successive frequently gets leg cramps, and somenot been suitable for a symphony concert Abrava-ne- l times in his arms. Is this something to Maurice Salute to Youth Concerts. (it was a sonata, for example) or that no an10th in the look into? He often plays on the floor No performer should be heard more matter how Mr. Abravanel tried to rearnual Salute to hftd I thought perhaps dampness caused than three times. This will permit his range the other numbers, he could not In it. Could it be lack of calcium? We give Youth Concert make a balanced program. being heard, for examDle, when he is 10, h t e Tabernacle. him a substantial amount of milk. When 15, and 20. In a word, the selection of the perwe massage him with a drug store The annual teenBecause the Salute to Youth Conformers to be auditioned, and those finalmusical highage cert" is the most prestigious musical ly selected, is product, that relieves him. Mrs. T. S. dependent on a number of is sponsored Answer: If he is getting plenty of light performance a student can have in Utah, variables. the Deseret by rethere are many students who want the milk, I would doubt that this is the Well, then, here is Mr. Abravanel's sult of calcium deficiency. (Ideally, a News. high honor. If Mr. Abravanel auditioned selections. And one of them is an excitwho After hours those of auditioning a should student who asked, he would hardget quart were youngster of this age for a first Salute to Youth recommended by the judges of the every ing of milk a day, including that which he ly be able to carry on his duties as music Concert. Because none of the singers 1969 Music Competition, Fair State Utah has on b'j cereal and in other forms.) conductor of the Utah Symdirector and are quite ready for a Tabernacle solo Maurice Abravanel announced late Monbelief phony. This is the reason that' he has Dampness, despite lcng-helperformance, he has invited four of them day night the names of those he has editors Louis the and causes- various trouthat dampness and, requested, to perform the celebrated invited to be guest soloists. Quartet the is director of not have State a factor. bles, Booth,, Fair, from Verdi s Rigoletto. of News have The Deseret editors the As the muscles tire, and subsequently agreed, that those he auditions will have The Program relax, they can go into spasm. Hence the suggested several flexible policies to Mr. first been screened through the annual Abravanel in line with their objectives Utah State Fair Music Competition and Concerto for Piccolo in C Major Vivaldi cramps.for the concert. These suggestions inthen recommended by the judges. with or withThe fact that massage Michael Vance, Ogden clude: out liniment or other such material Concerto for Viola Handel Every year some of those recomInstrumentalists should be under 21 mended to audition (and who have later him is an indication that this is Walker, Salt Lake City Joy e the type of cramping he is encountering. Concerto for Minor in E Violin years of age. Because so few singers are been a guest soloist) were not the .winners. Sometimes all three of the Just plain massaging is about as effecready at 20 for a symphony performance Mendelssohn tive as anything I know for such cramps. in the Tabernacle, Mr. Abravanel can se- - finalists in the advanced piano and First movement Barbara Ann Sudweeks, Salt Lake City Verdi Quartet from Rigoletto Brickman the small society by Marilyn Coward, soprano; Clearfield Angela Thomas, mezzo; Salt Lake City Terry McCombs, tenor; Provo Walter Rudolph, bass; Provo PIP Yotf e:VeK Intermission TAkfe INTO Concerto for Piano in C Minor, No. 3 Deseret News Music Editor Leg first-plac- d - first-plac- M$lP&ATiOM THAT MI6HT Beethoven First movement I HAVE Elizabeth Erickson, Provo for Piano Nc. 21 (K. ALEAPY Concerto PEAcH&PAW GOAL Life ? Wehinqln Suer Svieot r 9-- 25 ' First movement Susan Hunter, Salt Lake City I K enough when passengers all pretty the were little JirzJ Mr.- by girls. But two Law Firm - Jones Christmas, young boys were added to the list. One had a dog of no special breed except he was part elephant. Jle had to ba to grow so large. The 4twfr wouldn't go to school without his dog. Fido took up the entire passenger side of the front seat. Before, I could yell at By JACK ANDERSON kids to be quiet, but after fido started to . t WASHINGTON The Wall Street law ride, the yelling was out. If I said any; ( firm of Mudge, Rose, Guthrie, and Alexto an the as took it kids, that dog thing which served as the launching ander affront to him. He would push his hose of Richard Nixon1 pad for the up against mine and growl. is now cashing n on his new emiOnce I brought too many kids back nence. from school and had to hang on to one-,- , There is no evidence that the Presiuntil we could locate his parents. It was dent himself has lifted a telephone for about 9 p.m. before we found out who the his former firm or its clients. But corpoparents were. The mother wanted Tne 4 ; rations seeking federal favors are well held for kidnaping. - - -e in the aware of the Mudge-Rosposition It wasn't quite as bad in junior high scheme of things. school except the boys brought - along The prestigious old firm, having premice, garter snakes, frogs and the like:) viously disdained a political practice, Its nerve racking to be driving down the . , street and have a girl in back of you lejt, opened a Washington office at the same time Nixon joined the firm in 1963. out a scream like a banshee. Indeed, former associate Walter W. The worst part of this era was the Ahrens recalls that the two events ocSaturday movies. You not only picked uj) curred on the same day, although he your kids after the matinee, but all their swears this was strictly coincidental. friends. And no two lived in the same Nixons name came off the walnut direction. door of the Washington office soon after But now it is all in the past. OurA. his election. But the firm was less scruyoungest has her drivers license. ,vl i! pulous about the building directory, All we have to do is sit home and which still contains this entry: Nixon. worry until she drives into the carport. & Guthrie Mudge, Rose, Alexander, And you would be surprised how maqyMitchell. times I wish I was back in the school cat; suite at pool. From their plush fourth-floo- r 1701 Pennsylvania Avenue, the Midge-Ros- e Or would you? can attorneys and their clients gaze out upon the White House. This ; End nearness, figuratively as well as physically, has been a factor in the firms Reading the news these days makes mushrooming Washington business. Henny-Penn- y seem right the sky ) No one at the firm will answer ques, , might be falling down! tions about its operations. The secrecy is so tight that even the building custodian is under strict orders to giv- - out no infirm. formation about the Mudge-Ros- e v Booms In D.C. - Wit's "We dont want to talk about our business, resident partner Gerald B. Green-wal- d told this column tersely. The counbeen treated to a rash of absohas try lutely silly articles on this subject, and were simply not going to talk about it. Shortly otter Nixons election, Leonard Garment, a partner, was sent to Washington to supervise preparations for the expected boom. As a former associate put it: The firm wanted to broaden its dimensions. One insider explained that Garment was handling White House matters at the same time he was working for the law firm. Another insisted: Leonard worked strictly on political chores as long as he was at the iaw firm. The President advised him to remain with the law firm, pointing out he would make far more money directing the firms Washington practice. But Garment pressed for a White House appointment. Result: He is now a special consultant," earning $45,000 a year for his advice on human rights, minorities, and the arts. Despite Garment's departure, the e operation has continued to prosper. Late evening stroller along Pennsylvania Avenue frequently cgn see the firms lights burning well into the night. It is not unusual for Mudge-Ros- e attorneys to sign out of the building as late as 10 p.m. Grumped one Democratic attorney: The word is out that Mudge-Ros- e is in. ; BIG TALK This column has managed to dig out some of the facts, however, that the firm is trying to hide. Mudge-Ros- 467) Mozart Second movement . Jeffrey Moore, Salt Lake City Concerto fpr Piano in C, No. 3 Prokofiev , IN Nixon's Former '' , . Ivt pr-.,N- j r s ' ' t ? (' - By the time the average pilot; makes his bombing run over-- -' flown1 South Vietnam, he' rethree through two truces, e ond dnv sumptions, a cease-firescalation!" 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