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Show THE development of paralytic disease after the individual has received polio vaccine doesn't necessarily mean the vaccine failed. The disease may have been caused by a virus other than a polio virus, a recent University of Pittsburgh study has shown. Two properties heretofore believed be-lieved to be unique for polio virusesthe vi-rusesthe ability to produce paralytic par-alytic disease manifestations and the ability to produce similar antibody anti-body responses in the body were found to be shared by ECHO and coxsackie viruses. , The researchers explained that polio, Coxsackie, and ECHO viruses vi-ruses are all enteroviruses, which have many properties in common, including the ability to multiply in the human gastrointestinal tract with or without producing disease. Disease when It dues occur, most frequently involves the central cen-tral nervous system. Polio viruses have been believed to be the only ones to cause paralysis. ECHO and Coxsackie viruses have been associated with aseptic meningitis. In their study, the researchers found that six cases of paralytic disease orginally diagnosed as polio po-lio were probably caused by Coxsackie Cox-sackie and ECHO viruses These viruses, but no polio viruses, wore isolated from the affected patients The cases occurred during the 1952 field trials of gamma gobulin as a polio preventive. Three were considered con-sidered as gamma globulin failures, fail-ures, the authors said. Whether the enteroviruses Isolated Iso-lated in the six cases were the respective re-spective causative agents is not unequivocably established, they said. However, they were isolated during the acute phase of Illness, and, In the past, the demonstration demonstra-tion of a polio virus Infection during dur-ing the acute phase has been accepted ac-cepted as diagnostic. In addition to six cases of paralytic para-lytic disease, the researchers studied 10 cases of aseptic meningitis menin-gitis and a group of normal individuals in-dividuals for the antigen-antibody response produced by the entero viruses. They found that Coxsackie and ECHO viruses have antigenic constiution similar to t '. of polio viruses. (An antigen is a protein foreign to the body, whieh when it enters the blood stream causes antibodies to be produced to Tight it.) On the basis of their study, the researches said that in certnin situations, the Coxsackie and ECHO viruses may produce disease dis-ease similar to polio These situations sit-uations would be a combination of the unusually rapid spread of the viruses in the body andor unusual susceptibility of the human |