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Show Al4 The Salt LakeTribune NATION Friday, June 12, 1998 Drunken Flies May Help Scientists Understand Alcohol Tolerance in People THE ATED PRESS that the basic processesof life in such simple creatures often turn out to be virtually identical to the ones involved in more complicated animals, like humans. BOSTON — Drunken flies that carry a genetic mutation named “cheapdate” are helping scientists unravel one of life's myster- ies: why some people can hold their liquor better than others levels of a chemical called cyclic speck-size fruit flies act remarkably like humans on a bender. They become hyperactive and uncoordinated, buzzing about erratically. After a few minutes, they fall into a dazed stupor and then pass out. ‘Theseare, of course, just flies, A team led by Ulrike Heberlein of the Gallo Center (namedfor the flies — and perhapspeople, too — are especiallyapt to get inebriated if they naturally produce low but scientists have long known minutes to hit bottom. But the fruit flies with genes randomly cheapdate mutants tumbled down in 15 minutes. Francisco created thousands of knocked out. One oftheflies,it turned out, could nothold its al- Indeed, given too much alcohol The research found that fruit University of California at San cohol. They dubbed its genetic flaw‘‘cheapdate.” The researchersput flies inside a 4-foot glass dome — called an inebriometer — and pumped in alcohol vapor. The domeis crisscrossed with mesh landings. Ordinarily, the flies like to stay near the top. But as they got drunk, theyfell from level to level Ordinary fruit flies take 20 California wine family) at the Further researchfound that the easy drunks were missing a gene called “amnesiac,” so-called be- cause its deletion causes bugs to have poor memories. Flies missing this gene are believed to have lower than usual production of cyclie AMP, a chemical messenger known to be involved in many critical processes, including mem- sensitive to alcohol,” Heberleir said. “In people, it's been studied. butit's not so clear.” In a laboratory dish, alcoho! stimulates human cells to make ory and responses to some hormones. more cyclic AMP. However, long: term exposure has the opposite The study, published in Thursday’s issue of the journal Cell, is the first clear evidencein a living creature of a link between cyclic effect, making cells gradually produceless of the chemical. No AMPandreaction to alcohol. The one knows for sure if the same scientists blocked other steps in the production of this chemical thing happens inside the body. However, the fruit fly experiment suggests it does, said Hugo Bellen of the Howard Hughes Medical Institute at Baylor College of Medicine in Houston. and found these, too, made the flies more prone to drunkenness. “If you're a fly and your cyclic AMP levels are low, then you are | Make Things Feel Lighter Than to You Think! Guess You June \% Weight...And Can Have Me! With any Motorola Pager Purchase at Future Shop With any Motorola pager purchase over $19.99, Get a Free* Golf Tee Set! With any Motorola pagerpurchase over $30, Get a Free* Body Glove PagerSuit! With any Alphanumeric Pager purchase, Offers valid now through June 21st, 1998, “One bonus offer per customer, no dealers,not valid with any other promotional offer, not applicable to previous purchases. See in-store for details, oe - U Get a Free* Sleeve of 3 Titleist Golf Balls! VOICEMAIL _ H Sure : : Now You’re Talking! FORT UNION 7220 S. 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