OCR Text |
Show . The Kalina Sun, June A Look At Human Cancer County Commissioners Notes Of Action by Kent Petty Minutes of the regular meeting of the Board of Sealer County Commlnloneri held June 19, 1978. The meeting commenced at 10a.m. with all The following building permit applications were presented by the clerk to be signed by the chairman to be iurd: No. 101 to Kendal Hansen for a home In North Elsinore; No. 105 to Mr, and Mrs. Cordon Hatch for a summer cabin In Indian Creek; No. 135 to J. Gordon Hatch for a summer cabin In Indian Creek; Francis B. Winkel for a cabin in the Lost Creek area; Mr. and Mrs. Gerald B. Robinson. Jr. for a summer cabin In Indian board member and clerk pretent. Prayer uio offered by Commissioner Ivan Mills. The first order of business was the opening of bids for the Juvenile Court facility In the basement of the courthouse and auditorium. There were two bids presented. Don Munk Company, $61 .900. and D&D Contractors, $107,402 . The apparent low bidder was Don Munk Company. The chairman said they would like to have this 22 matter checked out with the County Attorney before any further action on this m alter. to present a new proposal for health Insurance for county employees. Craig Pettigrew, State Fire Warden, appeared to introduceRichard Llttke as assistant fire warden In this area for the summer months. Mr. Pettigrew i then presented a letter from Richfield City requesting a 6x6 4 truck from the state In ex- CMC truck change for a l'i-to- n that they now have. This truck has a tank on It, i and they said that due to the terrain they sometimes have to 4 get Into, they need something i with more power and ver-satlllty than the one they now have. The request presented n 5 was approved by the Board and signed by the chairman. Mr. ' Pettigrew then asked who In the county they should contact In Si case of major fires where they need some backup equipment f. i. from the county. They were In-- ! formed to contact Com-- y missloner Herring before any C equipment Is to be used from the Road Department. Clerk DeVon Poulson then a request factors hearing on county zoning, we have determined to suspend efforts to adopt the proposed land development code Including and subdivision zoning regulations, We remain concerned about growth problems within the county and will thoughtfully consider any recommended solutions. We express appreciation to members of the planning commission who have spent many hours over many months in developing the proposed ordinance all without compensation. It appears to us that at the present time the general opposition to zoning changes overshadows other concerns which we had hoped to address. Until such time as the public sentiment dictates otherwise, we feet duty bound to function within the framework of the that faulty existing zoning ordinance adopted in 1965. Adoption moved by Commissioner Dean C. Nielsen, seconded by Commissioner Elmo R. Herring. Carried S15 which must occur together. As mentioned in the last article, all cancer cells tend to exhibit a degree of dedifferentiation or regression toward the embryonic type. This, however, is a result of cancer, not the cause of it. The rapidity of metabolism and the extent of metastasis (invasion of other is termed the tissues) malignancy of the cancer. The nighly malignant cancers can spread rapidly and can destroy the individual in a matter of weeks even with treatment. The more malignant the cancer, the more dedifferentiated are its cells. Two highly malignant cancers, malignant melanoma and neuroblastoma, can, in rare instances, exhibit what is called spontaneous remission. In other words, they can of their own free .will disappear from the victims body leaving not a trace or symptom. They will sometimes never return during the individuals lifetime. More likely, however, they do return after a period of time ranging from months to years. When they do, they spread with a ferocity that takes the persons life very quickly. Many cancer cells exhibit a attending the recent public a 6 been found. The causative agent remains as mysterious as in the beginning. This in itself might indicate that the disease could have multiple causative Resolution In regard to Countaken at the regular commission meeting of June 19. In light of the strong opposition expressed by the overwhelming number of citizens C Ramona Oyler be approved as the new Deputy Circuit Clerk at a salary of $75Oper month. This was unanimously approved by the Board. : Richard Harris, U.S. Forest Servlce, appeared concerning Road Maintenance Cooperative Agreement. An example of one uia left with the Board for and for any changes !f- review S that are necessary. The Chair-y- . man said that they would take 5 this up with the County Attor-S- j ney and get this back to Mr. Harris. Terry Hopson, Forest appeared to review the 'RARE II Wilderness Program. He presented literature to the jjj Board for their review. The y Board thanked him for coming individual. If there would be one overwhelming description of cancer, it would be its consistent inconsistency. For over fifty years, researchers have looked for some universal detectable characteristic of the cancer cell. As of today, such has not ty zoning 1,000-gallo- presented Cancer is defined as a cellular tumor, the hormal course of which is fatal. Such a definition is not encouraging to say the least, but unfortunately, it is true. If all the cancer ceils cannot be removed from the body of the afflicted, the ultimate course is fatal to the Creek; No. 201 to Mr. and Mrs. Gerald B. Robinson, Jr. for a summer cabin In Indian Creek; No. 202 to Larry G. Gay for a cabin on the West Mountain, west of Joseph; No. 203 to Gene Higgins for a home two miles southwest of Elsinore; No. 204 to Farral Dee Gay for a mountain cabin west of Joseph; No. 207 to Norman R. Christensen for a summer cabin In the vicinity of Mr. Terrel; No. 208 to Wayne H. Hardman for a home near the South Brooklyn road; No. 209 to Allen Gurney for a home near Aurora; and No. 236 to Bill Hurley for a ummer home at Fishlake. Ray Roeller, representing Blue Cross-Blu- e Shield, ap- peared THE CANCER CELL glycolysis unanimously. .There being no further exerted), then; glucose unbusiness to come before the dergoes a different pathway Board, meeting adjourned at 7 converting it to lactic acid p.m. (through ten steps), carbon dioxide and energy. While the glycolysis through lactic acid can operate under conditions of adequate oxygen, it becomes a minor pathway. Many cancer cells follow the pathway to lactic acid as the major cycle even The bristlecone pines growing with an adequate supply of in California's White Mounoxygen. tains are estimated to be It was believed for some time more than 4,600 years old, in making them the oldest that this malfunction living trees in the world. glycolysis was the cause of cancer. This belief was discar- . Ser-;vi- , in. $ The Clerk then presented a beer license application by Robert D. Schmidt and Helmet Zimmer, doing business as Lakeside Resort at Fishlake. (S The Board reviewed this, and S upon motion of Commissioner 3 Elmo R. Herring, duly secon-- 0 ded by Commissioner Dean C. K Nielsen, this license uiaa ap- proved unanimously. SUMMER OUTING SUPPLIES LAWN FURNITURE Fishing altered enzymes, having erratic functional behavior. The membranes formed from the faulty decoding would no longer exhibit their proper selective molecular transport. Such an error in the transcription would vary the cellular functions from near normal for a slight error to totally abnormal for a large error. There is strong evidence that such genetic errors do occur in cancer ceils. These transcriptional errors might be due to an initiator enzyme alteration due to a hormone influence. Hormones produce only two effects in the body: (1) They regulate genetic activity. (2) They stimulate the adenylate cyclase system which controls the release of stored glycogen and consequently affect metabolism. The first function is most interesting with regard to transcriptional errors. The method by which hormones exercise their genetic influence is very complex and not fully understood. A very important cause of incorrect transcription is due to a virus invasion of the cell. Viruses are of two general types. They are either DNA or RNA types. They consist of either of these nucleic acids combined with protein molecules. Very succinctly, the two types function the same way. Consider the DNA virus which attaches to the outer cell membrane. It then injects its DNA into the cell. Due to enzymes injected with the DNA, the cellular DNA is ruptured and the virus DNA is This then forces virus DNA to be formed rather than the cellular DNA. Once the virus DNA is formed, it syn- thesizes the virus proteins, With both the DNA and proteins present, new virus particles are assembled within the cell. This either alters the cell chemistry and structure drastically, or it kills the cell with release of the new virus particles. Even if the cell is not killed, the new virus particles are ejected and proceed to infect additional cells. It is known that several forms of cancer are virus caused. It is interesting to speculate on the possibility that all cancers are virus caused by ubiquitous innocuous molecular fragments present in all cells, which suddenly can be assembled, by proper conditions, to produce a very virulent virus resulting in cancer. The error in synthesis can also occur in the codon sequences of the mRNA. This error might be induced in the mRNA even after correct transcripDNA. Some from tion possibilities for alteration are: Premature metabolic breakdown of the mRNA molecule; stored mRNA fragments in the cytosol are added incorrectly to the molecule after or even during transcription from d. process. Errors can also occur by ribosomal malfunctions by the incorrect reading of the LAWN GAMES CROQUET CAMPING HORSE SHOES PICNIC BADMITTON BARBECUE Pro-Hardwa- SAUNA, f DNA. If somehow the DNA is carrying the improper code or is transcribed to mRNA improperly by initiating the transcription too early or too late, all the protein synthesis (including the enzymes) will be incorrect. There will be isoenzymes produced, which are DNA; mRNA occurs with certain proteins which might play a role in the protein synthesis 9 lUo cycle. Glycolysis is the biochemical cycle by which glucose (sugar) is broken down by oxidation, causing the release of considerable energy. If the oxygen supply to the cells is adequate, the sugar is broken down directly to carbon dioxide and water with the energy release. If the supply of oxygen is restricted (such as in muscle cells when ded, however, when it was discovered that many cancers had normal glycolysis. The biochemistry of the cancer cell can be anywhere from nearly normal in highly differentiated cancers to almost totally altered in the highly dedifferentiated cancers. The cellular enzymes and membrane structures (composed of protein and lipid or fat) are essential to the biochemistry of the cell. The information necessary to synthesize all the proteins, enzymes and membrane structures is carried by the nuclear re UTAH initiator or terminator sequences on mRNA. Transfer RNA (tRNA) can also enter into the error process. In fact, it has been found that the tRNAs have a genetic regulatory function. Abnormal forms of tRNA have been found in every cancerous cell investigated so far. The biochemistry is complex involving isotransferases (abnormal enzymes involved with tRNA function) and alkylating agents (chemical molecules that add certain chemical groups called alkyl radicals) present in the neoplastic (cancerous) cells. Much work has been done toward somehow stimulating the bodys natural immunity defenses to protect against cancer. It has been shown that people with deficient immunal responses are far more likely to get cancer. We are all infected with cancer cells due to exposure to radiation, carmolecules and cinogenic genetic defects, but our natural immunity quickly detects and destroys the invading cells. If our immunity is inadequate, the cancer cells continue to .grow unimpeded. Cases exist wherein the cancer victim contracted a highly infectuous disease. The immunity reaction to the infection was so intense that it also cured the cancer. Many trials have been made to duplicate this response with lit- tle success. Since cancer appears to be of genetic origin, most treatments involve destruction of the genetic function of the cell. This is done by preventing the formation of either DNA, RNA, or protein synthesis. Once this is donethe cell will not divide and dies. Genetic inhibition can be accomplished by radiation radioactive elements, etc.) or by chemical means (chemo-therapyRadiation causes cross bonding between bases in the ladder structure of the DNA molecule. Chemotherapy does the job by introducing altered bases into DNA or RNA, thereby stopping the formation of these genetic molecules and stopping cell growth. Unfortunately, highly malignant cancer cells can subvert these treatments by probably rapidly metabolizing the drugs so that they become ineffective. Each generation of cancer cells become more drug resistant (more dedifferentiated), so even cancers that initially respond to treatment eventually become resistant, taking the individuals life. Surgery, of course, is the first line of defense if the cancer has not spread. Obviously, if all the cancer cells are removed by surgical procedure, a cure is inevitable. In conclusion, I would like to briefly discuss the controversial laetril glycoside (amygdalin). Laetril occurs naturally in the pits of the bitter almond, apple seeds, lima beans, etc. When broken down by hydrolysis, it yields glucose, benzaldehyde and the cyanide radical (electrically charged s, ). Page 4 PATIENTS SENDING HOME 2!l, 1978, SOONER-Reduci- ng heart attack hospital time could save $360 million a year in hospital bills and might produce less anxious, less depressed patients. Almost half of the 400,000 Americans who have heart attacks each year The first wallpaper it believed to date Christ wai uncovered at Master' Lodgings, in 1911. University, Cambridge could safely leave the hospital in seven days instead of the average two weeks, according to a Duke University study. t College, Ate you Coveted? Many heart attack victims would be psychologically better able to resume normal lives if they spent less time in hospitals, the study concluded. 0021 might reverse this and slow the growth of the cancer. At best, this probably would be its only effect. It was decided to omit latest research and drug developments due to the uncertain results of the discoveries. Southern Agency ROBIN MICKELSON, Agent SAUNA, UTAH ITMlffl if TOOTS The glucose would not affect cancerous cells other than to provide them with food for rapid growth. The benzaldehyde is definitely not carbon-nitrogen- an ). agent. This leaves the cyanide radical anti-canc- er which is highly toxic to the cell. The toxicity is due to the fact Theres a whole group of women out there whod prefer wearing hearts, stars, circles, squares, diamonds, or triangles In their newly pierced ears rather than plain, ordinary studs. that inactivates cyanide cytochrome oxidase, one of the vital enzymes of the cellulai respiration chain. Thus, if the cyanide is sufficiently concentrated, it will kill the cell. The logic says that since cancer cells usually respire more rapidly than normal, the cyanide would destroy more cancer cells than good cells. This is not necessarily valid since the cyanide radical is quickly destroyed by hydrolysis in the body. It is unlikely that etril will be found to have any properties. Vitamin C (ascorbic acid) on the other hand might have some beneficial effects upon certain cancers. The vitamin is a very strong reducing agent (the opposite of oxidation). Since cancer cells oxidize more rapidly than normal, vitamin C Earrings . . . i55 FREE PIERCING anti-canc- er AM Satina, Utah Whirlpool Appliances IN Stock nSEGStUCEID) KM 4A OF JULY SALE SAVE BIG DOLLARS! Hn-L- o Electric Co. 30 East Main Street Next to Moms Cafe in Salina t |