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Show could prove fatal for black men and othersat high risk for the dis- Study suggests that people should use both exams GANNETT NEWSSERVICE to seale AIDS virus study released WASHINGTON — A ease, a researcher said Wednesday. Instead, men with abnormal levels of a blood substance should not wait several months for a new shown about a third of the indi- large- Wednesday shows some low-risk individuals who submitted to both blood and urine screeningstested positive for HIV-1 antibodies in their urine, even while testing negative in their blood samples. ‘The clinical lab producing the test says the results suggest persons being tested for HIV-1, a viTus associated with AIDS, should have both bloodandurinescreenings. The Kansastesting lab — Clinical Reference Laboratory (CRL), one ofthe nation’s largest — said the study was the “largest to date” involving urine screening andthat about one of every 1,000 low-risk individuals in it tested positive for HIV-1 antibodies in their urine but not in the blood. Low-risk generallyis defined as people without multiple sex parthers, non-users of intravenous drugs and safe-sex practitioners. Presence in the urine of the antibody against HIV-1, said Rob- ert Stout, CRLpresident, “indi- cates, at the veryleast, a prior ex- posureto the virus.” Test results from two body fluids that do not agree are referred to by scientists as “discordant.” Stout said this is the first time HIV-1 discordant results have been confirmed in a large, lowrisk group. The urine test — manufactured by Calypte Biomedical Corp. of Berkeley, Calif., was licensed by the FDA two years ago. Calypte cosponsored the blood-urinetest- viduals contracting HIV-1 go on to develop AIDS. Others believe the percentageis higher. The CRLstudy tested matched blood and urine samples, and in 25,000 individuals found 24 samples negative by blood test, but positive throughthe urine screening. The urine-onlyreactive samples were repeatedly reactive, in further testing, for a particular should consider a biopsy techniquein which ultrasoundis used to target suspicious areas, accord- 24 percent of whites. Men who showmildly elevated levels of PSA — prostate specific antigen — in bloodtests often are advised to havethetest repeated in six months ora year But Littrup said any PSA in- methoddetects cancer better than His study of 2,368 black men and 1,090 white men, conducted cluding the urogentialtract. some people show antibodies in their urine, but not in their blood, relates to their ability to “compartmentalize” thevirus. 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Union (801) 565-0086 Mon.-Sat. 9-11, Sun. 9-9 Murray (801) 266-0075 * We've moved to He said by thesedrugs, Many peoplewiththese injuries have no symptoms, and up “There very important aspect of HIV-1 infection that has been overlooked,” shesaid. “The Louis, said sometimes ultra- there are reliable blood tests to detect cancer, and biopsies can cause inflammation and scarring, complicating later surgical procedures whileothers have shortness of breath and other symptoms. 95 long periods of time without in- University School of Medicine in sound is unnecessary. Fen-Phen or Redux WHOLESALE GROWER Florist Quality posed the “compartmentalization” theory, believes the virus may stay in mucosal tissue touched by urine and semen for the National Cancer Institute. But William J. Catalona, chief of urologicsurgeryat Washington Urgent newsfor people who. took POINSETTIAS Some scientists consider CRL tests to have important ramifications. They believe the fact that St. Once men have abnormal === linings in manybodycavities, in- slope,” said Otis W a medical oncologist lower PSA levels, when cancers repeatbiopsies the man is black. Prostate cancer “they are on what we calla specializing in prostate cancer at research saidthe test makes sense and could reduce the number of range, is suspicious, especiallyif PSA's, slippery Brawley, Hesaid the study did not com pare detection rates between the two methods. but proved ultra sound-guidedtherapy, along with color imaging, detects cancer at are morecurable. A physiciannot involvedin the crease, evenif it is in the normal is aggressive in black men. “Random biopsies are like shooting in the dark; you could missit,” Littrup said standard biopsies and should be over thelast four years, detected cancerin 31 percent of blacks and director of radiology research at Harper Hospital in Detroit and an associate professor at Wayne State University ing to a new study presented at the annual meeting of the Radiological Society of North America A large-scale study shows the type of antibody found mostly in mucosaltissues — the protective ing with CRL. contamination. Somestudies have test, as is usually suggested, but Te St Hl | in AS Thursday, December 3, 1998 used early, said Peter J. Littrup CHICAGO —_ Waiting for f blood tests to reveal prostate cancer re n NATION Urine Test Finds HIV Expert Urges More Aggressive Huntfor Prostate Cancer When Blood Test Can’t ® 1g sh The Salt Lake Tribune | Also visit our BARNESSNOBLE BOOKSELLERS mR ? cS |
