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Show | The Salt Lake Tribune NATION Thursday, December3, 1998 A5 Urine Test Finds HIV Expert Urges More Aggressive Huntfor Prostate Cancer When Blood Test Can’t THE s CHICAGO — Waiting for blood tests to reveal prostate cancer Study suggests that people should use both exams GANNETT NEWSSERVICE WASHINGTON — A largescale AIDSvirus studyreleased Wednesday shows some low-risk individuals who submitted to both blood and urine screeningstested positive for HIV-1 antibodies in their urine, even while testing negative in their blood samples. The clinical lab producing the test says the results suggest persons being tested for HIV-1, a viTus associated with AIDS, should have both blood andurine screenings. The Kansastesting lab — Clinieal Reference Laboratory (CRL), one of the nation’s largest — said the study was the “largest to date” involving urine screening and that aboutoneofevery 1,000 low-risk individuals in it tested positive for HIV-1 antibodies in their urine but not in the blood. Low-risk generally is defined as people without multiple sex partners, non-users of intravenous drugs and safe-sex practitioners. Presence in the urine of the antibody against HIV-1, said Robert Stout, CRL president, ‘indi- cates, at the very least, a priorex- posure to the virus.” Test results from two bodyfluids that donot agree are referred to by scientists as “discordant.” Stout said this is the first time HIV-1 discordant results have been confirmed in a large, low- risk group. The urine test — manufactured by Calypte Biomedical Corp. of Berkeley, Calif., was licensed by the FDA two years ago. Calypte cosponsoredthe blood-urine test- shown about a third of the indi- viduals contracting HIV-1 go on to develop AIDS. Others believe used early, said Peter J. Littrup, director of radiology researchat Harper Hospital in Detroit and an associate professor at Wayne State University Men who showmildlyelevated levels of PSA — prostate specific antigen — in bloodtests often are advised to havethetest repeated in six monthsor a year. test, as is usually suggested, but should consider a biopsy tech- 25,000 individuals found 24 sam. nique in which ultrasoundis used to target suspiciousareas, accord- But Littrup said any PSA increase, even if it is in the normal positive through theurine screen- ing to a new studypresented at the annual meeting of the Radio- the manis black. Prostate cancer is aggressivein black men “Random biopsies are like the percentageis higher The CRL study tested matched blood andurine samples, and in ples negative by blood test, but ing. The urine-only reactive samples were repeatedly reactive, in further testing, for a particular type of antibody found mostlyin mucosal tissues — the protective logical Society of North America A large-scale study shows the method detects cancer better than standard biopsies and should be range, is suspicious, especially if overthelast four years, detected cancerin 31 percent of blacks and 24percent of whites He saidthe study did not com. pare detection rates between the two methods, but provedultra sound-guidedtherapy, along with color imaging, detects cancerat lower PSAlevels, when cancers are morecurable. A physician not involvedin the researchsaidthe test makes sense and could reduce the number of repeat biopsies Once men have abnormal shooting in the dark; you could miss it,” Littrup said Fen-Phen or Redux cludingthe urogentialtract Some scientists consider CRL tests to have important ramifica- Doctors are concernedthat your heart may have been damaged by these drugs. Many peoplewith theseinjuries have no symptoms, tions. They believe the fact that some people show antibodies in whileothers have shortness of breath andother sym ptoms. their urine, but not in their blood, relates to their ability to “‘com- 95 | Ann Kiessling, of the Harvard Medical School, whofirst pro posed the “compartmentalization” theory, believes the virus may stay in mucosal tissue touched byurine and semenfor long periods of time without infecting the blood their legal rights. Pleasesharethis information with anyoneyou know valuedat approximately $100,000,000,is now being considered. Your legal rights havetime deadlines, so call today (open7 days/week) toll free from anywhereinthe U.S. at 1-800-THE-EAGLE for a free consultationto discuss your situation. Goldberg & Osborne is an Arizonalawfirmthat associates withexperiencedlawyers throu the US. to provide you withquality legal repre: ntation. GOLDBERG& OSBORNE TheInj Lawyers ” 1-800-THE-EAGLE Big and Beautiful virus can isolate and reproducein would be foundin tissue fluids that are not detected in standard shouldcall us to find out more about this test and beinformedabout who took these drugs. A groupsettlement proposal for some claims, and up “There is a very important aspect of HIV-1 infection that has been overlooked,” she said. “The prising that specific antibodies Doctors areurging youto havean echocardiogram to determine What care you may need. Every person who took thesediet drugs WHOLESALE GROWER Florist Quality partmentalize” the virus. tissues away from the blood Whenthis happens,it is not sur- PSAs, “they areon what wecall a slippery slope,” said Otis W Brawley, a medical oncologist specializingin prostate cancer at the National Cancer Institute But WilliamJ. Catalona, chief of urologicsurgeryat Washington University School of Medicine in St. Louis, said sometimes ultrasound is unnecessary. He said there are reliable bloodtests to detect cancer, and biopsies can causeinflammation andscarring, complicating latersurgical procedures Urgent news for’ péople who LCae His study of 2,368 black men and 1,090 white men, conducted linings in manybody cavities, in- Quality Flowers & Plants | (1-800-843-3245) . 1046 East 33rd South, Salt Lake| Offices in Phoenix & Tucson bloodassays.” Kiessling, who works at Har- vard’s Beth Medical Center, Israel Deaconess said this triggers ‘a general misconception that if ing with CRL. HIV-1 is a retrovirus spread by you haveanegativeviral burden sexual contact or through blood ally safe partner — that is totally contamination. Somestudies have could prove fatal for black men and othersat high risk for thedisease, a researcher said Wednesday Instead, men with abnormal levels of a blood substance should not wait several monthsfor a new in yourblood, you must be a sexu- wrong, and very dangerous > GranAen WY Ee A visit the new Barnes and Comfort Central is having a LENNOX High Efficiency Natural Gas FURNACE AND AIR CONDITIONING SALE. With 800 Lennox furnaces and 250 Lennoxair conditioners available for immediate installation at Year End December “SALE” prices. Call a Comfort Central Consultant today for a free estimate. llarere eyela Over 30,000 Music Titles. Books aren’t the only thing of note here. NaTURAL SIX MONTHS SAME AS CASH BY DESIGN Ge ectGas LENNOX on: vess 1Hin6 10 worny awour © Comfort Central HEATING - COOLING PLUMBING CALL(801) 'COMFORT”(266-3678). Doingit right... OR CALL TOLL FREE 1-888-428-6060 “Locally Owned and Operate” Now! Facainal Wh B ing! 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