| Show Nation Standard-Examin- Friday December 1 2000 1 3A Lab study: Bon© marrow cells can grow new brain cells Unexpected discovery shows how brains may already be repairing themselves naturally The Associated Press WASHINGTON - Researchers have discovered that transplanted bone marrow cells can migrate to the bram and turn into neurons a dramatic laboratory finding that may offer hope of new therapies for Parkinson’s disease and other bram disorders Two separate teams of scientists using different methods and different strains of mice have demonstrated that transplanted bone marrow cells can transform themselves naturally into neurons bram cells that carry nerve impulses - and install themselves seamlessly into the bram However h could take years before the researchers can prove that such transplants can be effective and safe for - treating human brain disorders they said The researchers said the finding suggests that converting bone marrow cells mto brain neurons may be part of a previously unknown natural healing action the body uses to replace failed bram cells “It may be a repair mechanism that is going all the tune at a low level” said Helen M Blau a professor at Stanford University and semor author of one of two studies appearing Friday in the journal Science Blau said the repair mechanism may not be powerful enough to correct “a really severe insult like an injury or Parkinson’s disease” but medical science may find a way to enlist this potential to replace neurons destroyed by disease or injury Dr Eva Mezey of the National Insti- Science agreed that the researchers may have found a way the body replaces neurons “On a certain level there might be a repair going on throughout life” said Mezey She said there’s no awareness of the repair because the process replaces a neuron as soon as the cell fails Tins process could be similar to the way the body constantly replaces dead skin cells with new cells she said The studies are the latest m a hot new field of research explormg the ability of adult stem cells to transform themselves mto other types of cells and to fill new roles m the body Bone marrow consists tute of Neurological Disorders and Stroke first author of the othfcr study m of at least two types of stem cells Earlier studies have shown these cells can f convert themselves into muscle bone and liver There also have been studies showing that neural stem cells can convert mto muscle or make a variety of brairi cells In Blau’s study at Stanford researchers obtained bone marrow from a strain of mice that carry in each cell a protein that glows in the dark This bone marrow was injected into the tail vein of mice whose natural bone marrow had been killed by radiation Later the mice were killed and their brains examined Failing school bodes ill for teens School performance and selection of friends are major risk indicators The Associated Press ! 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