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Show '' ' ' 8 Tuesday, February 18, 1947 DATLX ,. , HERALD Arrovtip Poison Under Study As Aid in Surgery . . CLEVELAND. O. OI.R) Curare, a South American poison vised by natives to tip arrows, is being studied tor its possible use in ' improving administration of an esthesia, particularly in such op erations as for cancer, stomach ulcers and gallstones. The investigation is being made by experts in the Western Reserve Re-serve University School of Medicine. Medi-cine. . The growing importance of the drug curare to medicine and sur gery has interested Dr. Harold Chase, assistant professor of pharmacology, in trying to find components of it which have definite defi-nite and predictable action; To" "that end, intensive research is being be-ing done, on .curare and its properties. Curare, whose history dates from the time Sir Walter Raleigh obtained the substance from South America where Indians had 'used it to tip darts and arrows, ar-rows, has had a reputation for variability. "This has limited its potential valuable uses,"' Dr. Chase said. In surgical operations in the region of the abdomen, curare may be given to relax the muscles so that the surgeon's hands can .move with greater assurance, Dr. Chase pointed out. Dr. " Chase explained, however, that curare "in its present state of relative impurity may be given in amounts that are either too large or too small to produce the desired effect." Too much of the drug may paralyze the muscles used in breathing, he said. Curare is a mixture of several alkaloids, and the object of the research has been to extract a pure compound from this variable mixture so that the effect of any definite amount prescribed will be predictable. The action of curare was first described about a century ago by the famous French physiologist, Claude Bernard. By experiments with frogs, Bernard reasoned that curare paralyzed nerves. Not much was done with cur are until the 1930 s, when Rich ard Gill, a cripple whose spastic muscles had been helped by curare, cur-are, went to South America to explore its source. He learned what plants .crude curare was extracted from and other secrets from Indian medicine men. Gift turned . his knowledge over to American drug houses, which have produced curare from the plant Chondodendron Tomento-sum. Tomento-sum. Although still only partially purified, the drug is now suitable suit-able for use by experienced physicians. phy-sicians. One of the more recent uses of curare has been in the shock treatment of schizophrenia and other mental disorders. In certain forms of shock treatment, fractures frac-tures of the spine have occurred. Curare, causing temporary paralysis, paral-ysis, reduced the violence of the muscular reaction. Dr. Chase has been investigating investigat-ing a series of ..synthetic drugs which might be as useful as curare cur-are and give more accurate results. re-sults. So far, nothing has been found. ; 4 : Legal Notices Probate and Guardianship Notices Consult County Clerk or the Respective-Signers fo? Further Information. In-formation. NOTICE TO CREDITORS In the Matter of the Estate of Joseph Clifford Greene, otherwise other-wise known as Joseph Clifford Green, Deceased, j Creditors will present claims, with vouchers, to the undersigned at the office of Geo. W. Worthert, Rooms 9, 10, and 11, Farmers and Merchants Bank Building, Provo, Utah on or before the 21st day of - April, 1947. DEAN SIMMONS Administrator of said estate. Published in The Daily Herald Feb. 18, 25, March 4, 11, 18, 1947. Strawberry ClbHi SIDE GLANCES VIC FLINT - -. torn, iw by we vic. me. r. m ra u. . wt of; The only thing I can suggest is that I?..0 i anA hav a movie made of tnem: Ubllwl 9Wi .. BY MRS. 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