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Show IHIM'I I WIHMW M I I Sun Advocate Price, Utah Tuesday December 17, 2002 9B Medical researchers discover gene playing role in gastric cancer cases Published in the Dec. 10 Proceedings of the National Alademy of Sciences, a Stanford Medical Center research study describes the discovery of a gene that produces less jrotein in the tumors of people who die early from stom-ad- h cancer. Samuel So, associate ;r. professor of surgery at the Stanford School of Medicine arid leader of the study, said the ; diwovery of the genes role in gdstric cancer could help scorchers devise treatments for the deadly disease. Stomach cancer ranks as the second leading cause of cancer deaths worldwide and the 10th leading cause of cancer deaths inthe United States, especially in Asian populations. The chances of living five years after being diagnosed with stomach cancer is only 20 percent, pointed out So. ; In the study, So and his colleagues at Stanford and the University of Hong Kong searched for genes that make either more or less protein in stomach tumors than in surrounding stomach tissue. The genes, which have different expression patterns in tumors, have led to novel treatments in some cancers, such as the drug Herceptin for treating breast tumors that produce a particular protein. The researchers first took tissue from 89 stomach tumors and extracted a molecule called mRNA from the cells. The mRNA molecule is produced by active genes and is eventually translated into a protein product The more of a particular mRNA in a cell, the more protein is made. r -- The medical researchers then attached a fluorescent molecule to the mRNA before washing it over the surface of a glass slide dotted with more than 30,000 genes. .When the mRNA encountered its corresponding gene it stuck to the area, forming a glowing spot. The more mRNA from a particular gene, the brighter the spot appeared. Upon comparing the pattern of- Spots between stomach tumor tissue and normal stomach tissue, the medical researchers found a single spot that did not exist in normal tissue but was bright in the tumor tissue, indicating that the gene is turned on only in tumors. When we looked at the data, the one gene stuck out like a sore thumb, explained So. r r i J r i - $ i i I r: i The medical researcher serves as the director of the Stanford University Asian t LiVer i i Center. National center details ways to protect children while shopping The team of medical researchers then divided the tissue into those with high levels made lower levels, comparing how long patients in the two groups survived. The medical study results indicated that out that 60 percent of those who made large amounts of the protein survived five years, compared with 20 percent of those who made lower levels of the protein It seems to have a very predictive pattern, added So. The question on researchers minds is what role the protein plays in preventing cancer, according to So. If So and his colleagues successfully work out the genes normal function, medical researchers could devise a way to either treat the cancer or better understand how the disease forms. Doctors could also test stomach for tumors PLA2G2A. The patients with low expression would be canease. Although So and his team do not fully understand the proteins role in stomach can- ed cer, past research findings show that it acts as a first line of defense against bacteria in addimice. The fact could help explain one mystery in stomach cancer. The common stomach bacteria H. pylori has been implicated in causinggastric cancer. But 25 percent of the individuals with stomach cancer have no signs of H. pylori infection. Therefore, PLA2G2A may help fight infection from H. pylon and an additional unknown g bacteria, noted - izruPA over-the-count- er l Are you advertising in markets that are doing you no good? Contact your local newspaper to find out how you can advertise on the world wide web and reach the local communities that your business needs. 1 UtahPress A S S O C I . 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Hors is what wo can do for you. ..Our specially trained read- ere find and tag any press reference to your subjects. The articles are then mailed, faxed or you can utilize our new CD ROM service. Call Utah Press Association for more informs- - a or upautahpress.com tion. f i . i O I Clipping Bureau A service of the Utah Press Association and your local newspaper BannerAd Network 5.. re- If the medical research effort results in a treatment or prevention strategy for the disease, it will benefit all stomach cancer patients. But the discovery of a treatment or preventative process will especially benefit the Asian population, which has the highest rate of stomach cancer. The disease ranks among the top five cancers in Asian populations in Californias San Francisco Bay area. So encourages people with stomach pain that is not be relieved by remedies to visit doctors for cancer screenings, particularly if the individual is of Asian descent or has a family history of gastric cancer. Localize The World Wide Web a in- So. www.utahlegalnotlces.com r- members. Give children a card with contact information, cluding cell phone numbers. The information will help security page or locate sponsible parties more quickly. cancer-causin- k - information booth. Teach younger children how to use a public telephone and stress the importance of looking for people who can help like a uniformed security guard or a sales person with a name tag. Teach youngsters to stay in the public view and never go to the parking lot looking for parents, friends or family tion to being active in other types of cancers in humans and The Utah Legal Notice Database Is online! Manual searches are free! Or, subscribe to ) Smart Search and receive delivery of dally local and or statewide legal notices of vital Importance to your Ibusinesa. Go to: i- with. Teach children how to stay safe and find help if needed. Make sure they know to stay with parents or responsible parties at all times while shopping and to always check with the person in charge before going anywhere. Make a plan. For older youth, have them meet the person in charge at a spot such as a sales counter or the mall didates for more aggressive treatment for the deadly dis- ) r During the holidays, schedules become more hectic and public places more crowded, making it difficult for parents to keep a close eye on children. "Like many parents across the country, I was disturbed by the number of missing children cases featured in the news this year. Hoping to help other families, I am partnering with the National Center for Missing & Exploited Children (NCMEC) and Philips Electronics to recommend that parents take a few extra minutes to capture their child talking, giving vital information about themselves and their unique mannerisms on video, pointed out actress Josie Bissett. NCMEC is utilizing Philips DVD recording as a tool to support families of missing and exploited children. "If a child is abducted or becomes missing for any reason, the national center along with law enforcement, can utilize the DVD with the childs image and other descriptive information to help get the search started immediately," explained Ernie Allen, NCMEC president. Families can benefit from transferring important information about children from a camcorder to a DVD disc. The holiday season serves as reminder to record a yearly update for children that captures distinct mannerisms, physical features and speech patterns. If needed, the DVD will provide law enforcement and the NCMEC with a useful resource with information about the child. The center offered the several tips for Carbon County parents to follow while shopping or traveling during the holiday season. Keep an eye on young children at all times. Always know where youngsters are and whom they are of the protein - called PLA2G2A - and those that A New Indispensable Internet Tool For Your Business! i 1 For subscription informatidn, call the Sun Advocate at 637rflZuJ f . ? P 90 Days Same As Cash 435-462-39- 29 hw btaatas . M FtM 1 345 S. Blackhowk Blvd. -- r- t 27, Mount Pleasant, Utah 84647 |