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Show ne NATION/WORLD New Mix of Drugs at Ce a The first of this family. saquin vir, was approved by the Food we akest of those in the pipeline None of the other protease inhibi tors has been licensed, although their approval is expected to be — ultimately. it is hoped, to a nor LOS ANGELES TIMES WASHINGTON — In some of the strongest evidence thus far mal life span. that a new generation of drugs can [ immunode: inhibit the human that powerful drug combinations virus’ reproduction an delaythe : six months after starting treat- tance inevitable and rendering ficiency virus, scientists Monday reported that HIVbecame virty. ally undetectable in most patients ment with oneof the new drugs in combination with two standard ones. For thefirst time we may be close to achieving almosttotal suppression of the AIDS virus in most patients,” said Emilio Emini, executive director of the antiviral-research division of Merck & Co., which makes indina vir — also knownas Crixivan — oneof the new drugs. Addressing the Third Conference on Retroviruses and Opportunistic Infections. Emini said that the virus could not be found in the blood of 85 percent of the patients who took thetriple com- bination, which also included the drugs AZTand 3TC. Experts believe that AIDS cannot be cured, so most have focused on slowing or eliminating disease progression through drug therapy. thus prolonging survival Thenewfindings bolster hopes Aslong as the virus has the ability to replicate, it can produce mutant strains, making drug resis- drug therapy ineffective. Researchers have been seeking ways to slow or stop replication, to blunt the resistance phenomenon and better control the disease swift Later this week, scientists studying another protease inhibi tor, ritonavir, made by Abbott Laboratories, are expected 5 to G aly ; data compelling equally Present although of a different nature: ‘hey will report that treatment Thwarting the virus’ ability to reproduce also will help maintain the integrity of the immunesys: tem for a longer period, so the body will beless likely to become vulnerableto infections and other diseases, experis believe The researchalso strengthens the view held by many researchers that the most effective way to combat AIDSis through combinations of potent drugs given as ear- President Jacques Chirac on Mon- day night announced a “definitive end” to the detonations. and raced to mendfences with other This will be thefirst evidence provide a clear benefit to pa- tients. They Schooley. program Acutely, work said Robert head of the scientific for the conference they work very well The strategy will be how to make them work over a longperiod of time. There is no question that this class of drugs is extremely tor, a powerful new family ofanti- virus at a late stage of replication viral AIDS drugs that scientists believe are many times more potent than the drugs that have been in widespread use for nearly a enzyme made by the virus, known as protease. Without it, the virus inhibiting the productionof a key is unable to make new infectious copiesof itself the White House press McCurry added that the deci our country and our childrenis momentumto our efforts to con clude a CTBTthat canbe signed this fall After months of defying the world with his nuclear tests. Chirac suddenly transformed himselfinto a leading opponent of assured suchtests. modern defense. Thesecurity of one of many countries in which his decision last June to resume nucleartests wascriticized Seeking to put the diplomatic damageof the tests behind him Chirac declared that “a new chap- teris opening. Francewill play an active and determined role for disarmament in the world andfor a better European defense In Washington, the White House welcomedthe French pres- tons of conventional explosives about six times as powerful as the atom bomb dropped on Hiroshi ma in 1945, Some scientists contend that underground fracturing of the coral reef at the nearby Mururoa GRIEF & MOURNING: Surviving the Loss of a Loved One Elizabeth Williams, A.P.R.N EATING DISORDERS: Dying To Be Thin Jane Blackwell, Ph.D. RELATIONSHIPS: A Healthy Approach to Finding and Keeping the Relationship You Want Don Strassberg, Ph.D FEB. 21st DEPRESSION TREATMENT: Medications, Exercise and Psychotherapy Joan Hadley, A.P.R.N FEB, 28th MAR.6th SEASONAL AFFECTIVE DISORDER: Breaking Through the Darkness Breck LeBegue, M.D. SELF-ESTEEM: Creating Your Own Pot of Gold Mauria Tanner, M.T.R.S The Effects of Marital MAR. 13th DIVORCE: Disharmony on Children Valerie Hale, Ph.D. MAR. 20th PHOBIAS: What To Do When the Monster's Under the Bed Mark Owens, Ph.D. MAR. 27th COUPLES THERAPY: Strange Bedfellows and Other Marital Issues Steve Ross, Ph.D. These free Wednesday evening presentations begin at 7:30 p.m. and are held in the Neuropsychiatric Institute's dining room as part of the institute's continuing commitment to bring the finest and most to the recent developments in mental health care community. ;: bathrobe-clad body was found in Kevorkian’s battered van outside the coroner's office Monday Linda Henslee, 48, of Beloit 7 of carbon-monoxi Wis Wi RS 1 ae i ae el ute Praemes. Se xaminer lJ. : 8 Her body was found around 6 investigation of the test sites by Charles Millon, the French de. fense minister, said Monday that all six tes had been “particular ly successful scientifically,” and that scientists would be ready to begin simulating nuclearblasts in a laboratory within months Pressure on the French government began soon after Chirac’s decision, last June, eight more tests to conduct fice and said to “check out the ve sheriff's Capt. Barnett Jones said It is the third time in the past year that a body has been left in one of Kevorkian’s vehicles near the medical examiner's office, in an area Sheriff John Nichols said has been nicknamed “Kevorkian Drive There's no observation of dig tied rges ‘ The University of Utah Neuropsychiatric Institute Lanratan ne SBS-2000 in tw counter She couldn't feed herself. She had no control over her hands,” she said Kevorkian has helped in the suicides5 of at least 27 people since 1990. Fieger refused to say if Kevorkian has attended other, unpublicized deaths her. ‘Why don’t you wait next week, next mont insisted. ‘My time is now ieger said ANNUAL SHEARING DAYS! nity to have tHe body of a woman dropped off at the morgue at 6 in the morning on a freezing day. It shows a ghoulish disrespect for the sanctity of human life prost cutor Lawrence Bunting said It was unavoidable. said Geof frey Fieger. the lawyer for the 67 year-old retired pathologist If arrangements could be made. for instance, to have the fu neral homes take care of these that perhaps could be arranged he said, But he said nursing homes. hospices and fu neral homes might have been un willing to deal with the bodies Fieger refused to say how where or when the woman died He said she was brought to Michi gan last week by two daughters and an unidentified friend The three. with Kevorkian. were pre sent when she Henslee died was diag multiple sclerosis nosed with years ago and by the time she died was com pletely incapacitated, unable to eat or use the bathroom without YOU WON'T WANT TO BUY A SINGLE THING AT THIS SALE, 50% OFF SECOND. ITEM [___NOW THROUGH FEBRUARY 3RD__| 50% O' ANY help, Fieger said You could just tell she was miserable.” said Lori Coolidge. a hairdresser whose shop is next door to the house where Henslee lived with her daughter Dawn was equivalent to about 120,000 invites you to share an evening with their experts FEB. 14th whose neide dit _ Fieg that I fore Kevorkian’s trial on assiste ly all nuclear tests The last and most powerful test at the Fangataufaatoll Saturday The University of Utah Neuropsychiatric Institute FEB, 7th sclerosis Coolidge said she shampooed “The day I came Henslee’s hair. Ver and did it. we just kind of had to flop her head over a eno effort” to persuade oth er countries to joinit in signing the treaty “to prohibit definitive- EVENING WITH THE EXPERTS JAN. 31st multiple She just couldn't do anything In a communiqueissued by his ffice. Chirac said France would Thedecisionfollowedthesixth and largest, atomic blast Saturday and came two days before Chirac is due to visit the United States. tests outside experts. McCurry, sion in Paris “will provide new haveat its disposal a viable and several other and sign a Comprehensive Test Ban Treaty [CTBT], said Mike drive to ban suchtests worldwide Withhigh drama, Chirac made the announcement in a nationally where by a global moratoriumonnuclear testing as we work to complete nations by vowing to lead the televised address fromthe Elysee presidential palace, saying that because of thetests, “Francewill atoll, were conducted, is more extensive than the French government has admitted Francehas allowed only limited secretary 97. that of a 48-year-old woman hicle in the parking lot.” ly after infection as possible. Indinavir is a protease inhibi- ident’s decision The United States has consistently urged that all nations abide vorkian took part in suicide Nc with a.m. after someone called the of France Ends N-Tests, Asks World to Follow LOS ANGELES TIMES PARIS — After completing six of eight planned nuclear-weapons tests in the South Pacific, French Ke Mich. — Jack death in patients with seriously depleted immune systems important. They are more potent than any of the drugs we've been using for the last nine years Protease inhibitors attack the decade \ ' PONTIAC, with ritonavir ma ily slowed the progression of disease and that using this class of drugs can A3 January 30, 1996 No Frills for Latest Kevorkian Suicide d Drug Administration in De mber. but is regarded as the a Tuesday is Happens 100 Years. |
