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The Salt Lake Tribune NATION sm Friday, March 9, 2001 AIDS Vaccine Shows Promise in Monkey Testing Immunization onfast track towardtrials on humans BY PAUL RECER ‘THE ASSOCIATED PRESS WASHINGTON Inastudy givingnew evidence that AIDS can be controlled by vaccine, inoculated monkeys stayed healthy despite exposure to high levels of virus, researchers say. The new vaccineis hemefast-tracked toward human testing. EDC: Americans Still Shirk Exercise In a report appearing Friday in the journal Science, researchers said the vaccine uses a one-two-three punch, with two shots to prime the immunesystem to resist the AIDS virus, and a final shot with a modified pox virus to boostprotection. Thefirst two shots use a vaccine containing DNAfor three proteins like those found in the AIDS virus. These proteins create a memory that prompts the immune system to attack when the proteins are later detected, said Harriet Robinson,senior authorof the study. The booster shot uses a modified government vaccine mayprotect against AIDS.” “Although the vaccine did not prevent infection, it continues to keep the virus at nearly undetectable levels for at least several months,”hesaid.“We do not know yet if this vaccine will work in humans,but proteins, she said. “Our results show that we can protect monkeys against an HIV-like virus using an immunization scheme thatis practical for use in people,” she said. Robinsonnoted, however,that the vaccine has not been tested for use in people already infected with HIV. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, said the study “provides someof the best plans for the necessary clinical studies are under way.” Robinsonsaidthefirst human trials are expected in less than a year. In the study, 24 monkeys were inoculated with varying doses of the new both HIV andSIV,a virus that causesAIDS in monkeys, and is widely accepted as a simian modelfor HIV. All four of the control monkeys developed AIDS and were dead within 28 weeks. All the vaccinated monkeys became infected with the virus, but their immune* systems, prompted by the vaccine, were, able to controlthe virus and the animals did not becomesick. 15-HOUR SALE eetel ‘THE ASSOCIATED PRESS the evidence to date that a preventive HIV teins added. This intensifies the immune system’s response against the AIDS virus STSaaa ea OESLaw Ey ‘ATLANTA — Justonein four U.S. adults exercised enough in the 1990s, smallpox vaccine with the three HIV pro- vaccine. Four other monkeys received’ only placebo. Seven months later, all the monkeys wereexposed to lethal doses ofa virus that mimics HIV, the virus that said Thursday. Only 25.4 percentof adults met government recommendations for physical activity in 1998 — virtially unchanged from the beginning of the decade, the Centers for Disease Control and Prevention said. 2-DAY STOREWIDE BONUS COUPON 2-DAY STOREWIDE BONUS COUPON ANY SINGLE SALE OR CLEARANCE ITEM ANY SINGLE SALE OR CLEARANCEITEM “HOME SAYINGS DISCOUNT 1.10% nA 10% OFF Almost 30 percent reported no physical activity atall. The CDC recommends a halfhour of moderate exercise, like walking, five times a week, or 20 minutes of vigorousexercise, such as running, three times a week. Analysts blame high-stress jobs coupled with lifestyle amenities that surfaced in the 1990s — from hundreds of cable channels to a multiplicity cf fast-food joints — for making Americans lazier. ‘People are spending more time ‘SmalBeces, Vac, Becrorics, PondCar, Fouts,ALCad Cookmare, Best Men's& Wormers Dckr®parts, Sats”pat, Men's8 Chiders Designer Colecios. 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