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Show 09, What is lactic acktosis and can it happen to me? pester agenre opanenhe ar Lactic acidosis a8s0- PATIENT INFORMATION ABOUT GLUCOPHAGE? year. Hts also important for our Inet be working normaly ven (metformin hydrochloride tablets) PHAGE.Your liver helps remove lactic acid from your bloodstre Trt wpve yodais na pre et on Fon time to time to make sure your kidneys and your liver are functioning norma A elesha ta bone ote 500 mg and 850 mg WARNING: : eannumber of people who have taken Glucophage ae ition cal acidosis. Property fu Moar wanoniecat pravent lactic acidosis. Moet people with id nay problems should not take Glucophage. (See Question Nos. 7-11) \ Q1. Why do | need to take GLUCOPHAGE’ , Your doctor has prescribed GLUCOPHAGE Gwe.-coe-fahj) to treat your type I diabetes. This is also known as non-insulin-dependent diabetes mellitus (NIDDM). 2. Whatis type tl diabetes? People with diabetes are not able to make enough insulin and/or respond normally tothe insulin their body does make. When this happens, sugar (glucose) builds in the blood. This can lead to serious medical problems including kidney dam‘age, amputations and blindness.Diabetes is also closely linked to heart disease. Themain goal of treating diabetes is to lower your blood sugar to a normal level. 03. How Is type i! diabetes usually controlled? High blood sugar can be lowered by diet and exercise, by a number of oral medications and by eee insulin Before taking GLUCOPHAGEyou shouldfirst try to control your diabetes by exercise and weight loss. Even if you are taking GLU- cet you should still exercise and follow ihea diet recommended for your diaot poe GLUCOPHAGE work differently from other glucose-contro! medYes ita‘Until GLUCOPHAGE (metformin hydrochloride tablets) was introduced, all the available oral glucose-control ee from the same chemical group called sutfonylureas. These drugs diood sugar primarily by causing more of the body's own insulin to be released. GLUCOPHAGE er tablets) lowers the amount of sugar in your blood by body respond better to its own insulin. GLUCOPHAGEdoes not cause your body He produce more insulin. Therefore, GLUCOPHAGErarely causes hypoglycemia (iow blood sugar) and it doesn't usually cause weight gain. 05, What happens if my blood sugarIs still too high? When blood sugar cannot be lowered enough by either GLUCOPHAGE or a sul- fonylurea, the two medications may he effective takentogether. However,if you are unable to maintain your blood sugar with diet, exercise and glucose-control crea ee then your doctor may prescribe injectable insulin to con- 06, Can GLUCOPHAGE cause side effects? GLUCOPHAGE,like all blood-sugar lowering medications,can cause side effects in some patients. Most of these sideeffects are minor and will go away after you've taken GLUCOPHAGE for a while. However, there are also serious, but rare side ties relatd to GLUCOPHAGE obe below). 7. What kind of side effects can GLUCOPHAGE cause’ It side effects occur, ey yg eefen wks of ty They are normally minor ones such as diar hea, nausea and upset stomach. Taking your GLUCOPHAGE with meais canrep reduce these side efcts, ‘Aithough these side effects are likely to go away, call your doctor if you have severe discomfort or if these effects last for more than a few patients severe decom dose lowered sap takin GLUCOPHAGEeter to orarly or permanently. Although these problems occur in up to one-third of patents when ty ra tart aking GLUCOPHAGE, yousti tel your dot # the problems come back or start later on during the the itr od tr ned eget har eng pena metalic taste when they start taking GLUCOPHAGE (06, Are there any sertous side effects that GLUCOPHAGE can cause? GLUCOPHAGE rarely causes serious side effects. The most serious side effect that GLUCOPHAGE can cause Is called lactic acidosis. 10. Are there other risk factors for lactic acidosis? Your risk of developing lactic ciesfrom takingGSLUCOPHAGE i vrlow a8 long as your kidneys and liver are healthy. However, some factors can yourrisk because they can affect kidney and werfnetonfou should otake GLUCOPHAGE f: © You have chronic kidney or iver problems . You cri lal excessively (alhe te shorterm “binge” drinking) + You are seriously lost a large amount of bodyfluids) SaaS ere hone cuter cir cone wih © You are going to have surgery «You develop a serious condition such as a heart attack, severe infection, or a stroke. Q11. What are the symptoms of lactic acidosis? ‘Some of the symptoms include: He ee Te eTac unusu‘al muscle pain, trouble breathing, stomach discomfort, feaing cox,teeing dizzy or wt or suddenly developing ofa a of irregu- is Seatiee Hf you notice symptoms, or if your medical condition has suddenly cto, op takingGLUCOPHAGE and cal your doctor night avy. Lactic acidosis is a medical emergency that must be treated in a hospital, 012. What does my doctor need to know to decrease my risk of lactic actdosis? Tell your doctor if you have an iliness that results in severe vomiting, diarrhea. ‘and/or fever,or if yourintake of fluids is significantly reduced. These situations can Jead to severe dehydration, and it may be necessary to stop taking GLUCOPHAGE temporarily. ‘You shouldlet your doctor know if you are going to have any surgery or specialie xray procedures that equi injectionofconst agers GLUCOPHAGE therapy will need to be stopped temporarily 013. Can | take GLUCOPHAGE with other tong osett a iICO we yw ibed or a change is made in how you take a drug already prescribed. GLUCOPMAGE may iter wih the vay some craps work and some drugs may inte fere with the action of GLUCOPHAGE. Fish Stories Although the subtitle gad of Cod: A Biogra- jaa phy of the Fish ‘That Changed the = C Od World (Walker and Co., $21) seemsto be a bit of an exaggera- markkurlansky tion, Mark Kurlan- § sky has written a sur- FP prisingly revealing accountthat should f interest previously unsuspecting fish- 5 eaters. Cod, especially off the eastern coast of North America, have furnished dietary staples, provided livelihoods, provoked commercial wars and political battles, and otherwise impacted countlesslives. This little book, stylishly written andneatly illustrated, will enable you to distinguish between cod, hake and whiting; tell how Cape Cod gotits name; eval the pros and consofcod-liveroi describe the origin offish and chips. It ne recounts the near demise not onlyofcod-fishing butalso ofthe cod itself in this technological era— a sad story. Interspersed among all this fishy data are an amazing variety of cod recipes, noneof which (at least to this un- practiced eye) look overly appetizing. 014, What If | become pregnant while taking GLUCOPHAGE? Tal your dott you plan becomeprognart of have become pregnant. As with ee RECORDING PTBcallyyour doctor will prescribe insulin while you are pregnant. As with all medications, you and your doctor should discuss the use of GLUCOPHAGE if you Having just seal violin salise eeee are nursing a child 15. Are thera other risks assoclated with GLUCOPHAGE? Tere is some evidence that any oral diabetes drug may increase the rik of heart problems. ‘are not sure what the real risk is for heart problems, if any, from taking oral diabetes medicine. (tzhak Perlman has lit fertile ina ahaa" Chroma Serenade is anew SonyClassical CDe- listing the collaborationof conductor Joba Williams aad the ESS phony Or- 016. How do | take GLUCOPHAGE? Your doctor wil tll you how many GLUCOPHAGE tabletsto take and bow ofan This should also be printed on the label of your prescription. You will probably be started on a low dose of nage ibe Reed ally until your blood sugar is 017. Where can | get more Information about ctfects. There is also a leaiet (package insert) your pharmacist can let you read. Glucophage is a registered trademark of LIPHA s.a. Licensed to Bristol-Myers Squibb Company. Revised June 1996 60600M-01 F5-B001-6-96 ® BristolMyers Squibb Company Distributed by Bristol-Myers Squibb Company 3 USA PAGE 20: SEPTEMBER 14, 1997 » PARADE MAGAZINE |
