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Show The Salt LakeTribune NATION Friday, June 14, 1996 Possible Test May Measure Strength of Lung Cancer ss Sh —_lung-cancer cells in test tubes can arrest their growth in a dramatic way.” Giordano said. So he used an antibodyto the protein the Rb gene produces to measure how active the gene was Alg in lung-cancer patients There was a strong correla between aggressive d low expression” of th explained. So people stronger|— d ally. smokers who Rb levels probaaly @ the most at risk for getungcancer, he added w els might benefit and riskier — thera Pa., whosays his moderatelevels BY LAURAN NEERGAARD THEASSOCIATED PRESS of the Rb protein maybe one rea- son his lung cancer has been in PHILADELPHIA — Discoverés of how cells fight off cancer remission for a year. “But I just wanted to know’ the results. aveled to the developmentof a Lung cancer kills 160,000 Americans a year, and cigarette ssible test to tell how aggres‘sive a patient's lung cancer is — ahd perhapseven predict who is The Hook-A-Book Summer Reading June 1 through August 31, 1996 cinogensin tobacco smoke caninjure genes that, when activated by ~The test, created by Antonio Siordano of Thomas Jefferson *Oniversity in Philadelphia,is sup=Bosed to detectlevels of a protein a mutation, can stimulate the growth of cells that are precur- sorsto cancer. portant for stopping cancer’s controlled cell growth. =The test is not yet available —a Seas companyis preparired for Food and Drug Adminration approval. But cells have built-in safety mechanismsthat are supposed to detect such mutations and stop them. These tumor suppressor genescontrol cell division — unless they are mutated so they «pewfindings on the different mol- Can the lack of a single suppressor gene cause cancer? Yes. e to do additional studies re- Drop by Deserst Book and pick up a free Hook-A-Book purchasing card and reading list. You'll be on your way to earning free children’s books. Remember, the more you read, the more you save! don't work either. = But Giordanosaysthetest is a first step. Ultimately, he hopes Sevulesinvolvedin a cell's life cy- said Carlos Cardon-Cardo of Me- *@e. including this Rb protein, will ‘ead to a genetic therapyfor lung morial veancer = “That is manyyears away,” Hook a Free Book at Deseret Book smokingis the chief cause. Research indicates numerous car- {host susceptible to tumors Sloan-Kettering Institute in New York Cancer The most well-known suppres- ac- sor gene is p53, but the retinoblastoma gene maybeequally important. he said. Originally Rnowledged Giordano, who plans xt month to report findings on )0 patients given his Rb test. He identified as the cause of a rare fave a preview Wednesday at a eye cancer, mutated Rb genes now have been discovered in “hheeting of biotechnologists. = More immediately, if additional breast, prostate, cervical and lung “ttudies prove the test works, he cancers Ride how tually theyare dedicated to a particular function in an organ. De- Simple cells divide until even- “said doctors may use it to help de- aggressively patients Should be treated I understand to the uncontrolled cell growth of tumors, said James DeCaprio of the Dana Farber Cancer Institute in Boston, who is experimenting with Rb in mice. Adding the Rb gene to human this is still fective Rb appears to allow those ‘differentiated cells” to start re- evolving.” said study participant ‘Norman Gross of Wynnewood producing again, opening a path Grandma The Family The Bellmaker. Run, Ducky, Tennis Shoes According to Mle.Lovingly told from a child's point of view, this story portrays the special bond between a grandmother and her granddaughter. A winning combination of text and art just right for families looking for books to read together. Paper. $4.99 Reunion.ByIncia Tusa. When two mystery guests show up at the wacky Beneada family reunion, the fesult is a riotous comedy of errors. This delightful picturebook will entertain readers of all ages. Paper. $5.95 By Brian Jacques. An epic quest that takes Joseph the Bellmaker and a courageous band of Redwallers across land and sea to help Mariel the Warriormaid. Where a vicious Foxwolf and his bloodthirsty rat hordes have claimed the kingdom as their own. national bestseller for young adults. Paper. $5.99 Ruin.Ducky decides to tun for class president not realizing that Marybeth, a fellow Bee There, is also run‘ing. Her plans to throw the election only succeed in making her more popular. A hilanous adventure for girls ages 8 to 12 by Lael Littke. Paper. $6.95 and the Feathered Serpent, book two. By Chns Heimerdinges. Join Jim Hawlans and family in _this concluding volume. A spectacular Book of Mormos epic that races to a breathtak ing climax. A best-selling senes for LDS young adults. Paper. $11.95 Ask us about Lagoon Discount Passports. Available at Deseret Book. ‘There's Onty One. 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