| Show Contest Uetayea-Hdcas- e QJemAZOL& capsules In ptamncokiMlic chidtes ot ot apprexxtoMy fouriOM ant noted Asa kubteett vtictiliilf aitim mwtaiwa ot hwlnt ol waphagta k a wtai AUC Odn adtatm td taw to corso4 ntwctj r PRILOSEC to Moated tar toon-toWould Rented m lump mAk I Dociust of tto pdBntnJ tor aanous adaarsa naebans to nursmg aitoms h ahoam tor omepraiote m tat caromogeracAy W ot dBConhnue the drug Wong mlo account the UK Salary and ettectinness in padmncp Bug to than to lie OS chncal M poputohon ol 466 patonts rmctodmg duodenal ideer &tonger- nsK m(MW nd itsstMt oiccr piticntsK ngadreneeapanences men mported to occur minor dm ttay WLOSECN hyanashgators as ) Numbers possibly parentheses tndicaCe percentages of tha or detuuetymltoao to tha drug m probably Teens: Your story Prn cou!d win $2000 to assooM tto dowloomara a " Wtota dwipy to wtota vtoo tat dmpy ascoptotUy totong “"N tooMtadoMdrasBtantoctortoratnyansdaioiistnkdoriuictpliMtytetoiigBnotpossbktoernai gpy jyw MM- (Saa tto ctonttvomyo package aiaoa MKR06IOL06Y nctoa) CaWia Uttar PRILOSEC BindlcaBd lor short-toor anna bomoooastneulcar koto tratoiaia(4-ilo- ) USoUmmoftotml Rsiw Itoriar (GBNf Yrntoftoe 6ERD - PRILOSEC ionj'caod to too Mtoatbui aid oltor symptoms askoutoa) anti SERO twin toisHgllu-PRILOSto idicitd tor Tto aiwoptogito uAvcb toe tow dagnosed by otPRILOSEC wad tor longar tton onto at thesa patonls has not tow astatoshad In ttonmaslwdooia whom not responding to 8 amhs or tnatnmL may to totoful to gm op to w additional 4 amoks ot Matmanl N than s recurrence ot aroarm asoghagto or GERO symptoms (e g heartburn) oteMtonH 44 week coursaa of oawpraala man ha uoattoraiL UWalaaaaw mUaaHai tofiaBtatoaptagta PRILOSEC is Mcatnd to r PRILOSEC J5 "J8" anti ctonthrtvnyun la more Itoty to wall y0 Are you a teen who eryoys writing fiction? Would you like your original story to be read by 45 million people? Then enter USA WEEKEND’S sixth annual Student Fiction Contest for Entries will be judged grades by editors of the magazine and Contributing Editor Wally Lamb Lamb who has taught writing to high school and college students is the author of the best sellers She’s Come Undone aad I Know This Muck It True y and opwlatoL Release Capsules an ocnttssWuted OCCURS WHILE TAKING CLAHtTMOMYCN PATIENT SttOOLO APPRISED OF POTENTIAL HA2AR0 TO FETUS (Sto WARWN6S la pnsarjhmg latorwilHa atanttaaryda) i SERIOUS ANO OCCASIONALLY EATAL HYPERSENSITIVITY (anaphylactic) REACTIONS REPORTED IN PATIENTS ON PENICILLIN THERAPY THESE REACTIONS ARE MORE LIKELY TO OCCUR IN WOIVKHIALS WITH A HISTORY OF PENICILLIN HYPERSENSITIVITY ANDOR A HISTORY OF SENSITIVITY TO MULTIPLE ALLERGENS BEFORE INITIATINS THERAPY WITH AMOXICILLIN CAREFUL INQUIRY SHOULD BE MADE CONCERNING PREVIOUS HYPERSENSITIVITY REACTIONS TO PENICILLINS CEPHALOSPORINS OR OTHER ALLERGENS AN ALLERGIC REACTION OCCURS AMOXICILLIN SHOULD BE DISCONTINUED AND THERAPY INSTITUTED SBUOUS ANAPHYLACTIC REACTIONS REQUIRE KMFOtATE EMERGENCY TREATMENT WITH EPNEFHRME OXYGEN WTRAVENOUS STEROBS ANO AIRWAY MANAGEMENT tCLUOMG ItTUNAnON SHOUIO ALSO BE AMRWSTEREO AS WtHCATEO (Saa WARNINGS at presenting towmetioa lor AnomvcnXvta Peettoiaimkrutn asWa tea naartsd wth aaarta ' K IK to t taoxnta) aaNtoatoM taw b to agsma aad mag nags amrarity tom wM la ttotoaatorlag Ttontoa 0 la topartaatla a n pWaato ato pmaaal add Otortoe aatosawM Is tto adtalaiatoltot at aawactoial S m pnacnUng uAaratahon lor ctoWromyda aad wumtoi) to Symptomatic nspoms to OHtapy uctric I with omtpnrcls Oosa not pncluda tto pnaanca ol MU tolom aahng Pahams should to cautioned that the PRILOSEC Capsule shouWnot to tanned ehatnod or crashed and Would to tMUmted athola On tatoKtfaar Ottor -- OmepnnXa cw prolong the and phenytoM drags that am ntataOolaad hy oxidation in Although in normal aahiacB no attaractnn mth thaopliyllma or ptopranolol aaalound than have tow tnporttot Intaraetlonmtholhar drugs matahoUnd tto da cytochrome P4S0 (eg cyctoaponaa dsulfiram dwapines) PWants shoo id to momtond to datermaa A B necessary to adpto tla dotage ol these drugs wlan tatonconeomtoitly anth PRSOSEC Becaoaa ol protoond and long tasting Mhtl ton olgtihicaod secretion A to thsonhcaly posata thu onapranto may totertin mth ahsotption ol Buga athengaatncpHlawi tort detarnman or tlaa OiostoiatiiMy (a katoconaxoto antpcrirt esten and iron salts) In da dmical mate antacids en wad conconaamiy wdh the admmstnhon ot PRILOSEC CaaNaattoa Tttarng ato Clap at omeprazoto wd ctenlhromycm Iwn lasultad at atemasas at plasma totals of NAnaayctp oaapra20to etanthromyem and 14Hiydroi)hclanthromycai (Saa CLINICAL PHARMACOLOGY Pharmacoto-mmComhaiaMR Tttrtcy ato AnUmatals at tod Prascntotg Momahon) Concomtant admmahalion ol elandtioniycin anth osapnda ptmoada or Hrtenadma to eontrtondrctoedL Than lava tow nporta ol w intoae-E1arythromycm and aatamgola eaButtaag In OT protongataa and lotaadas da pointoa- - Concomdant admlnatradon ot arythromycln and astoneoto to contramdKatad Because dtntwomycln to ako metaholaad da rath asteniBotoa not reconanended (Saa also cytochrome PasoconcornrtjrtadminettalionalcIthUirornyaii CONTRAINDICATIONS Oanthromyca aoova Ptaasa ntar to ltd ptascnOitto Womudton lor dtrrttitomycia) total raaele toailraiararfartaNy: la two BAwordh ctremogemcity ttudas at tatt omapra-M- a at dady doses of 1 7 34 13 B 440 and 140 B tngAmday (appmotnualy 4 to 352 hraas da humw doat hasad w a patam weight ol SO Ig and a Henan dose ol a mg) produced gastric ECl cad wetooidt manner doth mala and tomato rale da mctdanca ol tha altoct aas martadly higher tomato rada atoch tad hrglar blood totals ol omepmole Gatnc catctnotda seldom occur m da undetoad nt In addition ECl cad hyperplasia aas present at al treated groups ot doth sent toona ot these ahidas tomato tils warn tnated with 13B mgAgslay omapratoto (apprnnalely 35 anas the humw don) tor 1 year dan Mowed lor w addmonU year Mho ttwdnq No carcmotdsaen saw m these rats An increased Incidenoeot d ECl cad 10 hyperplasia aas otosned at the and ol 1 year (94 treated controls) By the aacoml yaw the ddtonnea hetman treated and corniol reams much smaller (46 vs hut shi showed more hyperplasia in the heated An unauU primary matgnant hmor m the stomach was aew in one rat No santor tumor ms saw gimm m male or tomato Ms treated lor 2 yean For tha stnm ol nl no samtor tumor has dean noted hrstoncWy hut a Unrhng myolwog only one tumor b duheue to MerpraL A 7Bweelt mouse carcatogemctly study ol omepnak did not show mcraased tumor occunonce hut tha study ana not conchSM Omapnaola ma not mutagenic m w to "do Amw Satonns tahamnum assay w at Mm mouse lymphoma cad assay and w m Wont Over DNA damage assay A mourn mrctonuctous tost at 625 wd 6250 times tha humw dose gam a borderline maud as lid w at imp hone marrow chromosome aberration torn A second mouse metonudeue study to 2000 draw tto humw doaUut wdh ddtonm (suhoptmiU) sampling hmes eras negatne Ftopneary: Omepmaele: Pnananee Caaegeeg omepmole In a doae nnge ol 6 9 to 691 nWday (approiomatoto 17 to 172 dm me humw dow) produced mcnaaaa In antoryoHathahty tool resorptions and pregnancy dtoruphone In nta amhryoAetol ttanoty and postnatal deustopmental taacity enn ohsened m odsprmg raeuding from pannta healed mth omepranto 138 to 138 D mgAgrday (approommely 39 to 345 tones die humw dow) Then am no adonuate or wIEcomioied atmtoa m pregnam ammen Sporadto nporta tan tow ncemd of manta born to worm ho ton mooned omepranto during pregnane congerml abnormalities occurring Omeptsrole should to wed during pngnanqi only B the ocaantal heneht msuhsa the ponnttol nek to tha toua Baa WARNIN6 (above) and Ml Pngaaaag Catapary C pnschtwig aitormatton for baton ouig m stagnant ammo Mmtog AMtac d to not toioam eiielhm omapmoto excreted m humw mite to rats otnepmoio achtwsliaiMi durmg toe gestation and hetohoa at doaaa m 136 la 136 myug'day (35 to 345 hmaa the humw dose) reaudadmdecreaaadawght gam ai pups Becaun many drugs an a am a ad tt g - ""r'liWA a a 26) - niyisma dxmiWa n kiti w O Asm PhannacauecalaLP 1994 2631 pabems and amyects raernnd m attach Causal Ratodonship nm Assessed patonts wth "" IK 2 1 9-- in patmata wth a laioaio nyperesnsmvdy to toy iMcrokdt anMht Coacormtat admaaatrahori ol darahtomychi L pvnoadk or tartsaadsa B comnaatcataiL Itora have haw poaHaartotmg reports ot drag tnta-- n danthromiaw aadlor ayfotontydn an ootomaastared aadi osapnda ptmonde tertensdme gmcaroac arrhythmias (OTprolongatioa porrtes) most hkeN this to mhtbmoo of hepatic metabohsm to mesa drugs hy arythromycm and ctaidironiycnL Fsahnes han tow nponod (Ptoaao rater to did pnscnhmg bitormahon tor etanthromyem before pnecnbmg) UBhaaWcaWt la patonls with a hmtoty at attogc nactoo to any ol the parwtwp a ratal to hill ptatcribmg vdontobou tor amomclw betas pranertwg) WMUSfc fterMrenpste: CLdHtTHROMYCM SNOULD ROT K USED M totEStUWr VOMER EXCEPT NtCfJNICAL CWCUI4S1AIICES WHERE IIO PLTBUUnVE THERAPY to APPROPRIATE PREGNANCY IK mala ctoacto of Advene &penencas tala toabng ot arosraa nsoptogdts Cotdrotod startoa do am wtaad beyond 12 months aacMaqr Cwdtoaar PRILOSEC is Mated for the toagtom traWasm ot palhoiogato I tooeM ZokngerGtasoA syndroms multiple smtocma adwomas wd system mastocytoss) MWMHCW talpnnta PRILOSEC Detoyed tovoMkypsttonsiOvrtytoaiyixiiripontaolltoloimuttbon arJl Bison syntiWM monto Weieiii InobNPt of dnodoMl potato toaunduadireoto Sow patonls moyrenun at adteboniMuMlB of Bmpy PRILOSEC too jtoh ctortfmmyat wd tonoedta to nutated to totomd to panto wth H mon ntoebo mH idoar dsttto (acbw or w to PRILOSEC to tomtotWoB mW taskxy) to etvhcato H woMl too ndcokd tor mama to ptoenta and) M pyVon aitacOon wd doodeml ton town to adn tad Itorapy m djleaaOKlwaimongi (2) s s occurring ol paheiAs or subnets domeshc andor international tnate or system In mwy mstwees tha nduding nreiy anaphytom (see atoo Stan Detow) lewr pain tobgua malaise abdonanal smteng Chnapaaseutor Cheat pan or angatetachycaidia hndycardit patpdabon elevated blood presaum paripherU edema GawomtoslBiaT Pancnabts (some total) hntable colon Aatulenca local teacotoratioo anorexia asophageal caKdahaste mucoaal atrophy of the tongue dry mouL hiring tremmem wdh omapratoto gastnehnue gland polyps have been noted rvete These ooW an tomgn and appear to he nversdito whw treatment B discontinued GastnHhiodanal carcinoids have toon n patients with 2E syndrome on treatment with PRILOSEC Ties taxing believed to be a n ol the underlying conddnn which to loioam to to assoewed with such turnon Mild and Nepal s m bver hmchon tosto (ALT (SGRT) AST (SGOT) rghdamyl tnnspoptidaaa totahno In nm nuances overt bverdtseaae has occurred mckiding hepatocellular necrosis (some tool) hepahe tenure (soma tool) and hepahe “yponabanue hypoglyceiiaa arngm gam AhrscutoMHat pan tog gam Nerwur SystonuFtoyclMInc Psychic i 4lions contusion insomnia eervousni knee anxiety dnam abnormalities vertigo: parsstheete henabcai dysesthesia A pan Star Raw and only cases ol seven genenteed alon nacbona toctodmB 1 (TEN: soma total) GtevansUotmaon syndrome and etythema muddorma (soma MW pettchiie jsorrnwith rectallenge) start mtlammabon latcana angioedema pruritus alopeca dry slun hypen tadrosB SoeaalSwisei Taaabis taste perversion UrogwiNat lntBratilial nephntto (soma with posaive rechaE tenge) umary tract toteebon mcroacopic pyuna urinary Irequency alevatod serum cteabnna pnMxma L glycaaurto kabanar pan gynecomasoa Hamtootogic' Ran instances cl pancytopenia agnnutoey-nem- a kucncytoss and hemolytic anenaa have tom or tnpla iDwwtaHpytafraftcjhondiWtherwywithPRiLOSECandclai wdh PRILOSEC etanthromyem and amomcihn Adverse expenances that have occurred hove haw ctordhromyelnoramoxiollm Tr Therapy (miioSSOclKmimfenfmmcitm): The moat Ireguant adverea experiences observed m dmeal tntos using combmetmn therapy with PRILOSEC ctordhromycto and amoncWn (n 274) wan dantaa (14) taste and headache Nona to these occurred at a higher fteguency thw Nat nportad by patients Wong da antxnicrobal drugs atone (Aaf Therapr (muOSCOdtnmmvany Adaarsa exptnencas otowred in controtod ctoacto Inals using combination therapy wdh PRILOSEC and etanthromyem Ri 346) which difletad trow dx prewusiy described lor omepranto stow wen testa poraersion (15) tongue dBcotonbon Wormadon on dardhromycm or anioaabwta in 1 in the drug ana martotod an ahoam bekwr anthm each body jtoamPRILOSEC ans imcloir BatfAst Whole Allergic reactions '"l Grand Prize winner Your story will appear in our June 1 issue and you wiD receive a $2000 college scholarship s Five finalists: Your name teacher will be announced in that same issue and your story will appear at nl — story title usaweekendcom You’ll receive a $75 gift certificate for books or software Teachers: Sponsors of the winner and finalists will receive a $50 gift certificate for books or software — (7) How to enter (2) Submit an original story of no more than 1500 words A substantial part of the action must be set in the present and in summer The language must be appropriate for newspaper readers You must write in English using good grammar and spelling Thestory must be typed double spaced on 8Vi-by-- 1 paper using just one side Also send a cover sheet with your name address and phone number as well as the name address and phone number of your school and the name of your sponsoring teacher if any You must be enrolled foil time as of Feb 142000 in an accredited public private parochial or home school grades 2 Vbur entry must be received no later than Febv 182000 !f sent by regular mail address it to USA WEEKEND Student Fiction Contest PO Box 4532 Blair Nebv 68009 Entries sent by overnight mail go to USA WEEKEND Student Fiction Contest DXBlairJobNo9074 1548 Front St Blair Neh 68008 (phone: No purchase necessary Void where prohibited tan reports have how received td overdosage wdh omapraibk Doses ustareconunandad ctoacto dosajtawieaationa wan aatlahto JPFHBGBASfc ranged ftom 320 mg to tonw tto Wmg but included drmmwbhand wsrwjachycmito aausea teaphoresa flushing headache and ihy mouth Symptoms wen danaant and no aanous chnaal outcome las hew reported No spacdic antidote lor omepramto oventosaoe toioam Omepraioto b wdenaiaaty protem hound and b ttonton not naddy teatoabla la tto want ol owr- dosage tnabnem should to symptomatic and supportive Idarf term NaateraafaFAcWwBtoadaaaliaBarTlaiiiieraiaiinvriiraiua wa dow of PRILOSEC B 20 mg once darhx Most patterns heal anthm 4 weevs Some patients may nouns 4 weehs of therapy ee INDICATIONS AND USAGE) RMrctarai pytari badiatai tad erOaeUtta Trtpto Therapy (PRILOSECidanthromycm tanoncWin): The recommended adud orel reQanwu PRILOSEC 20 mg Wadanthroniycat5iX) mg piuaamoxdllin 1000 mg each green twice baity lor 10 days In patontt anth wtocerpnsant to tto dma of natation of dmpywadddional 18 days at PRILOSEC a WKWIHWTITIWi tt IfAmmnca £ ta ta tototorAs wdhwulca present at the lima el natation of therapy maddaonto 14 days of PRILOSEC 20 mg once OHtotom nlal Pleasa reler to dardhromycm did prescnbuig infor-mahoa tor CONTRAINDICATIONS and WARNING and lor Informwon regarding dosing In siderty wdnnaly dnpamdpabento (PRECAUTIONS: Sevwrai PRECAUTIONS’ SenamicUsewd PRKAUTlWfS- Onm taaraWota Ptoaao rotor to amoxlcitoi tad praserdwig mtormaton tor CONTRAINDICATIONS and WARNINGS fiasfrte Otter The recommended adud oraidqseto40 mg once a day tor Ato 6 weeds (Sea INDICATIONS ANO USA666asoic lbtam Weuaw Tto recommended adud oral dcae tor tto treatment nl tawnetepbapnaf daily tot up todwaaia Tto recommended aduh orto dose lor tto treatment of oatienewilhenwivaMcnrmiiiii: ana mvvvnuvma— vernn to 20 mg tody tar 4 to 6 aneha (Sw INDICATIONS MOteAGE leeptayteto Tto reconaneadad adud oral dose B 20 mg dady Patea riirto NtoerwaHtoiV'fwtetaw Tto dosatotoWILOSECmpatontt ante palhologictohyparstatacoiidilicwvamwimtamibaidutooWwt Tto ncommandWaMl oral starting dose 60 mg ones a day Oases should to adjusted to individual patont weds and should coreinue totaa tong as cbnlcalyladicalod Poses ap to 120 mg tid Daily doaagw of gnater tton BO mg should to adnhasared in dwlded doaaa No doaaoo atfetotmanl Mcaasantar pabems mth renal toipalniieiiLhepeticdyahiiiction or tor the eidethr J'! (tar - s Astra OsMtotodtec Wayne Phermaceubcate PA 19067 LP ntf USA December 1996 MTHN--— in ' — Merck 6 Co Inc WtoatPlwdPA1B4BIUSA For complete rules go to usaweekendcom PRBI Ailfghtonaamd - 535 Madison Ave New York NY 1 002Z 14 USA WEEKEND Fetx 442000 a |
