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Show Sun Advocate Price, Utah Tuesday October 15, 2002 9B Researchers discover cause of celiac sprue disease v mortgage rates in cause and a potential treatment ' for celiac sprue, an autoim-- . mune disease that leads to an nability to digest gluten, a ma-o- r protein in wheat, rye and arley products. . The disease is estimated to afflict as many as 1 in 200 Americans. In the Sept. 27 issue of Science, researchers identity a fragment of gluten called gliadin as the celiac culprit. The researchers showed that the fragment is resistant to digestion and is responsible for inflamg the matory response experienced by celiac patients. The investigators also report the use of a dietary enzyme made by a bacterium that can break down the fragment into harmless bits, suggesting future Utah Housing Corporation U making families, said Erickson. fixed morttory by offering the lowest "Unfortunately, wages in Utah have not gage interact rates since the state finance .kept pace with the rising cost of living. That means the downward trend in interest rates is agency was established 27 years ago.. The fixed mortgage rates are S. 17 percent even more critical in Utah than elsewhere in with two discount points and 5.47 percent with the country. At UHC, our goal is to help work'. no discount points.1 ing families get into their first home, and, in UHC is ecstatic to be able to offer these many cases, offer them financial assistance to incredibly low rates, commented William cover the upfront costs, added the state fiErickson, agency president Our organiza- -' nance agency representative. tion assists 1b quality for UHC loans, the applicants families, who have g been excluded from the arena household incomes must not exceed a certain level. . because of their income, in purchasing their first home. The low rates finally open the door licants should also have a reasonably for these families to achieve die dream of audit rating, purchase a modestly priced home ownership. and be able to afford the expenses assoLow and moderate income families in ciated with owning a home. The Utah Housing Corporation is a pubUtah are among 18 million Americans in need of decent, affordable housing, according to lic corporation that offers multiple resources to develop and finance affordable UHC In the most recent survey conducted by the housing for low and moderate income people National Housing Conference, statistics in- residing at locations throughout the state. home loans for UHC finances dicate that one in seven American families e buyers. spend 50 percent or more of annual income thousands of on housing or live in substandard condi- UHC also allocates state and federal income tax credits to finance the development ' , tions. The report, entitled Housing America 's and rehabilitation of affordable rental hous; Working Families: A Further Exploration , ing. found that the number of families needing Since the agency was founded by the Utah housing has remained virtually unchanged Legislature in 1975, UHC has provided fisince 1997. nancing for more than 65,000 single and Relatively high interest rates, rising hous- housing units. . For information on UHC mortgage loans, ining prices and the inability to save an adequate r amount of money to cover downpayment and come and purchase price.restrictions along with dosing costs are the biggest obstacles for most a list of participating lenders. Carbon County first-tue at homebuyers, pointed out the state residents may rail the state agency ' brochure. a free for finance ' agency representative. Local residents may also obtain additional The average mice for a single family home in Salt Lake Qty has skyrocketed to $187,594, by visiting the UHC website at home of for out reach ownership many wwwoitahhousingaxpxKg. putting his- lower-inco- 30-ye- ar . lower-inco- home-buyin- non-pro- low-intere- st multi-fami- try and chemical engineering at Stanford. Graduate student Lu Shan was lead author on the paper. ly insects and mites seek protected sites to spend the winter. Among the group of pests seeking a cozy spot in yards across Carbon County are squash Many plant-feedin- g bugs, Mexican bean beetles, ear-wig- s, strawberry root weevils and spider mites. But local residents can take action now to get a jump start on pest management for the next gardening season. Remove herbaceous annual plant materials at the end of the season. Do not leave vines, plants and annual flowers in debris piles. Compost or dispose of the plant material as soon as possible. The longer the debns is around, the longer many pests have to find a comfortable place to spend the fall and winter. Rototill your garden soil in ; pipe-lik- needed, a plant becomes more vulnerable to winter injury. Keep a record. Plan now for next year by keeping a record of garden plants and cultivars you liked best and those with the fewest problems. Also keep track of pest problems (such as aphids, scale, pearpsylla and red mites) that should be treated next spring with dormant oil sprays. ed I intestine. The e re- duced surface area keeps the body from absorbing nutrients. Often diagnosed in childhood, the disease can lead to the distended stomach and stunted growth typical of starvation. The only effective therapy for most people is a lifelong gluten-fre- V HARVEST BALL at the p restrictive, explained Gary Gray, professor of medicine, emeritus. The diet is essential during ELKS LODGE Sponsored by Castleview Hospital or j October 26, 2002 - Saturday 23 East 100 North, Price, Utah and a special thank You lo the Relief Society. 70cc6, James A. Ferro PhJ). our fate HeAAU Prizes & FUN Costumes Optional October 14. For more information call The Family Support AChildrene e&Li&v-- i al. (435) .. A. Qetue THE EXPRESSWAY GROUP NEEDS Experienced OTR Drivers & Owner Operators tJPtice' with CDL Class A. Excellent Routes - Repetitive Customers or SAFE FACTORY OUTLET CKBI-ILTA- you N UOWN-WH- 110102 "doiuT-wii.Ion -- Rad -- Iran L - White (untlncf) iirpw GKANDIORENING Let J 61x6, 6x8 home log econdi! Great for 4. beds, cabins, etc. Call today & well play Make a Deal! Homes Satterwhite Log - eax roil free (435) http:www.fatterwhite-log-honiea.co- t - LI 1 Satterwiiitc Log Homes has a limited quantity of 3x8 fit 3x6 Siding. i IMMSllilaakMSMMM -- 2ccL- Deal . 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Bosses Week begins to me and my family at die loss of my precious Hour 7 p.m. Dinner 9 p.m. Dancing Boss Week. express my love and appreciation to the many people for the acts of love and kindness shown nutrients to the soil In late winter to early spring, jne diseased and dead limbs woody shrubs and trees. 6 p.m. Social has some greatideas for you to celebrate I sincerely wish to son, Charles. Thank you for the gifts of food and flowers, and thank you for traveling so far to show your love and respect for Charles, Justice Center present's their annual I thats fairly diet, and e The Family Support & Childrens $25 per person $200 for table of 10 pests. Continue to water perennial plants through the fall Although s perennials growth by bringing them to the surface where they will dry up or freeze. ' Plant a M and winter cover crop such as annual ryegrass. The cover crop reduces weeds, retains soil moisture and adds C&nical sanraaiidiaDttEcfeflS in turn, tends to make these plants more prone to attacks by the fall. This destroys many pests that can overwinter there . i e, is slowing and less moisture is water-stress- Pl WERDOTERfrURNSRUORDTRle Stanford researchers as well as a group from the University of Oslo in Norway. The lining of the small intestine is normally carpet-likcovered with small protrusions called villi. Celiac disease, however, results in a smooth, fall gardening practices curb spring insect problems pointed out the Stanford graduate student Because the fragment is rich in the amino acid proline, the investigators reasoned that a peptidase (an enzyme that breaks down proteins) with the ability to digest proline-ric- h chains might be able to break down the gliadin fragment rendering it harmless to celiac patients. The study shows this is the case in test tubes and in rats. Because there are no animal models of celiac disease, testing the approach in humans is a long way off and will require further predinical work, according to Khosla. We think that this mode of therapy - peptidase supplementation - may offer hope in treating celiac sprue eventually, and were going to test this hypothesis, concluded the Stanford chemistry and engineering z!toacflito6Wtaiihiiftt The team included other toll-fre- Wait until the woody plants have hardened off for the winter before pruning. Fhll pruning may predispose plants to winter injury. Protect shrubs and other roots plants with winter-sensitiand crowns, such as roses, blackberries and grapes. Place leaves, grass clippings or other types of mulch around the base. Winter injury will cause stress and reduced growth for cold susceptible plants next spring. This, When the researchers looked more closely at the fragment Shan and her colleagues found that it was made up of even smaller fragments already noted Chaitan Khosla, professor of chemismal life, T-ce-lls i to attack the intestine. The team in Norway then measured the ability of the gliadin fragment to induce autoimmune activity. was "The response by about 10 to 20 times higher than the smaller peptides them- selves, The Stanford graduate student identified a protein fragment made up of 33 amino acids that was resistant to further digestion and whose structure was known to be toxic. Most proteins are broken down into small peptides of between two and six amino acids' or into single amino acids. Shan then repeated the study in rats and again in test tubes using tissue taken by biopsy from patients undergoing unrelated medical procedures. Even with prolonged treatment (exposure to intestinal enzymes), the peptide doesnt lose the ability to induce the inflammatory response, indicated the Stanford graduate student supplements. These findings are the first step to giving people with celiac disease real hope for a nor- known to induce human T-ce-lls cess, exposing gliadin to digestive enzymes in test tubes. treatment through dietary first-tim- ne In the laboratory, Shan simulated the digestive pro- intestine-damagin- fit low-incom- e, By DIANE ALSTON Utah State University Extension both to restore the long-ternormal intestinal function and reduce the risk of developing osteoporosis, lymphoma or cancer of the small intestine, added Gray. A team of investigators led by Stanford University researchers have discovered the 528-50- 03 ni Advertise Here! Statewide!!! 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