Show I 1 A new local anesthetic obtained from froman an Indian plant called gasu basu has recently been submitted to careful examination examination ex ex- by some Hungarian dentists The anesthetic action pf this substance nce was discovered a year ago by a dentist in Flume Flume Dr D. D Dalma who Dalma-who who tried the effect of gasu-basu gasu in cases of painful and recommended it as a powerful agent which might replace arsenic in the treatment of that condi condi- tion Dr Dalma also separated the active principle of the he plant which proved to be an alkaloid and in hIs later experiments he used the salt obtained obtained ob oh- tamed by treating the alkaloid with I hydrochloric acid This salt has been named nervo In weak solutions solutions solutions 10 1 of 20 1 per cent produced a marked local anesthesia of the cornea of warm warm- warm blooded blooded animals Two drops of a 20 1 per er cent solution applied to the human produced produced produced pro pro- a burning sensation accompanied by followed after twenty minutes by anesthesia of the cornea lasting for five hours After seven hours the cornea regained its normal condition A 10 1 per cent so solution solution solution so- so lution of brushed over the mucous membrane or the cheek caused local anesthesia of the brushed surface and of the tongue accompanied by loss of the sensation of taste and the perception perception per per- caption of touch but without loss of the perception of heat and cold Attempts to produce local anesthesia by subcutaneous injections of I dine In animals have not yet been suc sue The general action of i dine on the system was that of bf a poi pol- son producing death by paralysis of the motor centres of the nervous system I and of the nerves All the experiments proved that was a powerful local anesthetic which had the advantage of producing a i J much more more sustained action than cocaine co caine for the effect of 4 Vz or 5 1 per cent solution might last for two or three days It is however not without It its it drawbacks such as the local Irritation to which It gives rise the slow production production I tion of the anesthetic state from ten I to twenty minutes being required and anda a liability to the occurrence of nausea nausea nau nan sea vomiting salivation and other symptoms of general poisoning Lon Lon London I don Lancet |